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dc.rights.licenseopenen_US
dc.relation.isnodoubledee058ed-fdeb-4b9b-8e81-645d067921d4*
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorTALAGA, David
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorSMERALDA, Willy
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorLESCOS, Laurie
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorHUNEL, Julien
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLEPEJOVA-CAUDY, Nad'a
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorCULLIN, Christophe
ORCID: 0000-0003-4110-4677
IDREF: 85920959
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorBONHOMMEAU, Sebastien
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLECOMTE, Sophie
dc.date.accessioned2020-04-08T09:35:55Z
dc.date.available2020-04-08T09:35:55Z
dc.date.issued2018
dc.identifier.issn1433-7851en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/4163
dc.description.abstractEnThe morphology and secondary structure of peptide fibers formed by aggregation of tubulin-associated unit (Tau) fragments (K18), in the presence of the inner cytoplasmic membrane phosphatidylinositol component (PIP2 ) or heparin sodium (HS) as cofactors, are determined with nanoscale (<10 nm) spatial resolution. By means of tip-enhanced Raman spectroscopy (TERS), the inclusion of PIP2 lipids in fibers is determined based on the observation of specific C=O ester vibration modes. Moreover, analysis of amide I and amide III bands suggests that the parallel beta-sheet secondary structure content is lower and the random coil content is higher for fibers grown from the PIP2 cofactor instead of HS. These observations highlight the occurrence of some local structural differences between these fibers. This study constitutes the first nanoscale structural characterization of Tau/phospholipid aggregates, which are implicated in deleterious mechanisms on neural membranes in Alzheimer's disease.
dc.language.isoENen_US
dc.title.enPIP2 Phospholipid-Induced Aggregation of Tau Filaments Probed by Tip-Enhanced Raman Spectroscopy
dc.title.alternativeAngew.Chem.Int.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/anie.201809636
dc.subject.halChimie/Matériauxen_US
bordeaux.journalAngewandte Chemie (International ed. in English)en_US
bordeaux.page15738-15742en_US
bordeaux.volume57en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248
bordeaux.issue48en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03184340
hal.version1
hal.date.transferred2021-03-29T11:44:44Z
hal.exporttrue
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