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Photodegradation of novel oral anticoagulants under sunlight irradiation in aqueous matrices

dc.rights.licenseopenen_US
dc.contributor.authorYASSINE, Montaha
dc.contributor.authorFUSTER, Laura
dc.contributor.authorDEVIER, Marie-Helene
dc.contributor.authorGENESTE, Emmanuel
dc.contributor.authorPARDON, Patrick
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorGRELARD, Axelle
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorDUFOURC, Erick
dc.contributor.authorAL ISKANDARANI, Mohamad
dc.contributor.authorAIT-AISSA, Selim
dc.contributor.authorGARRIC, Jeanne
dc.contributor.authorBUDZINSKI, Hélène
ORCID: 0000-0003-1028-9154
IDREF: 070478090
dc.contributor.authorMAZELLIER, Patrick
dc.contributor.authorTRIVELLA, Aurelien S.
dc.date.accessioned2020-04-07T15:56:16Z
dc.date.available2020-04-07T15:56:16Z
dc.date.issued2018
dc.identifier.issn0045-6535en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/4154
dc.description.abstractEnKinetics of photodegradation of novel oral anticoagulants dabigatran, rivaroxaban, and apixaban were studied under simulated solar light irradiation in purified, mineral, and river waters. Dabigatran and rivaroxaban underwent direct photolysis with polychromatic quantum yields of 2.2 x 10(-4) and 4.4 x 10(-2), respectively. The direct photodegradation of apixaban was not observed after 19 h of irradiation. Kinetics of degradation of rivaroxaban was not impacted by the nature of the aqueous matrix while photosensitization from nitrate ions was observed for dabigatran and apixaban dissolved in a mineral water. The photosensitized reactions were limited in the tested river water (Isle River, Perigueux, France) certainly due to the hydroxyl radical scavenging effect of the dissolved organic matter. The study of photoproduct structures allowed to identify two compounds for dabigatran. One of them is the 4-aminobenzamidine while the second one is a cyclization product. In the case of rivaroxaban, as studied by very high field NMR, only one photoproduct was observed i.e. a photoisomer. Finally, seven photoproducts were clearly identified from the degradation of apixaban under simulated solar light. (C) 2017 Elsevier Ltd. All rights reserved.
dc.language.isoENen_US
dc.subject.enPhotolysis
dc.subject.enSolar light irradiation
dc.subject.enSurface water
dc.subject.enApixaban
dc.subject.enDabigatran
dc.subject.enRivaroxaban
dc.title.enPhotodegradation of novel oral anticoagulants under sunlight irradiation in aqueous matrices
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.chemosphere.2017.11.036
dc.subject.halChimie/Matériauxen_US
bordeaux.journalChemosphereen_US
bordeaux.page329-336en_US
bordeaux.volume193en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03180125
hal.version1
hal.date.transferred2021-03-24T16:41:39Z
hal.exporttrue
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