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In vivo screening of multiple bacterial strains identifies Lactobacillus rhamnosus Lb102 and Bifidobacterium animalis ssp. lactis Bf141 as probiotics that improve metabolic disorders in a mouse model of obesity

dc.rights.licenseopenen_US
dc.contributor.authorLE BARZ, Mélanie
dc.contributor.authorDANIEL, Noëmie
dc.contributor.authorVARIN, Thibault V.
dc.contributor.authorNAIMI, Sabrine
dc.contributor.authorDEMERS-MATHIEU, Véronique
dc.contributor.authorPILON, Geneviève
dc.contributor.authorAUDY, Julie
dc.contributor.authorLAURIN, Émilie
dc.contributor.authorROY, Denis
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorURDACI, Maria C.
dc.contributor.authorST-GELAIS, Daniel
dc.contributor.authorFLISS, Ismaïl
dc.contributor.authorMARETTE, André
dc.date.accessioned2019
dc.date.available2019
dc.date.issued2019
dc.identifier.issn0892-6638en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/3840
dc.description.abstractEnGiven the growing evidence that gut dysfunction, including changes in gut microbiota composition, plays a critical role in the development of inflammation and metabolic diseases, the identification of novel probiotic bacteria with immunometabolic properties has recently attracted more attention. Herein, bacterial strains were first isolated from dairy products and human feces and then screened in vitro for their immunomodulatory activity. Five selected strains were further analyzed in vivo, using a mouse model of diet‐induced obesity. C57BL/6 mice were fed a high‐fat high‐sucrose diet, in combination with 1 of 3 Lactobacillus strains (Lb38, L. plantarum; L79, L. paracaseil casei; Lbl02, L. rhamnosus) or Bifidobacterium strains (Bf26, Bfl41, 2 different strains of B. animalis ssp. lactis species) administered for 8 wk at 109 colony‐forming units/d. Whereas 3 strains showed only modest (Lb38, Bf26) or no (L79) effects, Lbl02 and Bfl41 reduced diet‐induced obesity, visceral fat accretion, and inflammation, concomitant with improvement of glucose tolerance and insulin sensitivity. Further analysis revealed that Lbl02 and Bf141 enhanced intestinal integrity markers in association with selective changes in gut microbiota composition. We have thus identified 2 new potential probiotic bacterial strains with immunometabolic properties to alleviate obesity development and associated metabolic disturbances.—Le Barz, M., Daniel, N., Varin, T. V., Naimi, S., Demers‐Mathieu, V., Pilon, G., Audy, J., Laurin, E., Roy, D., Urdaci, M. C., St‐Gelais, D., Fliss, I, Marette, A. In vivo screening of multiple bacterial strains identifies Lactobacillus rhamnosus Lbl02 and Bifidobacterium animalis ssp. lactis Bf 141 as probiotics that improve metabolic disorders in a mouse model of obesity. FASEB J. 33, 4921—4935 (2019).
dc.language.isoENen_US
dc.subject.engut integrity
dc.subject.eninsulin resistance
dc.subject.endairy products
dc.title.enIn vivo screening of multiple bacterial strains identifies Lactobacillus rhamnosus Lb102 and Bifidobacterium animalis ssp. lactis Bf141 as probiotics that improve metabolic disorders in a mouse model of obesity
dc.title.alternativeThe FASEB Journalen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1096/fj.201801672Ren_US
dc.subject.halChimie/Matériauxen_US
bordeaux.journalThe FASEB Journalen_US
bordeaux.page4921-4935en_US
bordeaux.volume33en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248
bordeaux.issue4en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-02510708
hal.version1
hal.date.transferred2020-03-18T08:57:25Z
hal.exporttrue
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