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Adsorption of Proteins on Dual Loaded Silica Nanocapsules

dc.rights.licenseopenen_US
dc.contributor.authorRAMALINGAM, Sathya
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorLE BOURDON, Gwenaelle
dc.contributor.authorPOUGET, Emilie
dc.contributor.authorSCALABRE, Antoine
dc.contributor.authorRAO, Jonnalagadda Raghava
dc.contributor.authorPERRO, Adeline
dc.date.accessioned2019
dc.date.available2019
dc.date.issued2019
dc.identifier.issn1520-6106, 1520-5207en_US
dc.identifier.other10.1021/acs.jpcb.8b12028.en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/3800
dc.description.abstractEnThe design of nanocarriers containing hydrophobic and hydrophilic compounds represents a powerful tool for cocktail delivery. Water-in-oil-in-water emulsions constitute an attractive approach, as they offer dual encapsulation and provide a template for the constitution of a capsule. A limitation in the preparation of nano double emulsions is their instability resulting from high curvature radii. In this work, silica nanocapsules (NCs) stable over several months were synthesized. This was achieved by exploiting a double emulsion in which the oil phase is constituted by a combination of oils presenting several volatilities. The decrease of oil droplet size by evaporation favored the deposition of a silica layer at the nanoscale interface. The release of the payload obtained by drying the capsules was investigated by fluorescence spectroscopy. Understanding the interactions between proteins and nanocapsules is a fundamental point for many biological applications. Nanocapsules were exposed to two model proteins, which were bovine serum albumin (BSA) and lysozyme (Ly). These proteins, presenting differences in charges and size, showed distinctive arrangements onto the nanocapsules. Moreover, we have studied changes in α-helix and β-sheet content, which divulged the interactions between the proteins and the nanocapsules.
dc.language.isoENen_US
dc.title.enAdsorption of Proteins on Dual Loaded Silica Nanocapsules
dc.title.alternativeJ. Phys. Chem. Ben_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1021/acs.jpcb.8b12028
dc.subject.halChimie/Matériauxen_US
bordeaux.journalJournal of the Chemical Society B: Physical Organic Journal of the Chemical Society B: Physical Organicen_US
bordeaux.page1708-1717en_US
bordeaux.volume123en_US
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248
bordeaux.issue7en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03181441
hal.version1
hal.date.transferred2021-03-25T14:56:19Z
hal.exporttrue
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