Health state utility and quality of life measures in patients with chronic myeloid leukemia in France
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FOULON, S | |
| dc.contributor.author | CONY-MAKHOUL, P | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GUERCI-BRESLER, A | |
| dc.contributor.author | DABAN, M | |
| dc.contributor.author | KAPSO, R | |
| dc.contributor.author | TUBERT-BITTER, P | |
| dc.contributor.author | BONASTRE, J | |
| dc.date.accessioned | 2021-04-26T14:47:56Z | |
| dc.date.available | 2021-04-26T14:47:56Z | |
| dc.date.issued | 2021-03-02 | |
| dc.identifier.issn | 0962-9343 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/27109 | |
| dc.description.abstractEn | PURPOSE: Tyrosine kinase inhibitors (TKIs) have dramatically improved the prognosis of chronic myeloid leukemia (CML). We aimed to assess health state utility and quality of life (QoL) in French patients with CML in real-life setting, to study the determinants of utility score and to compare health-related QoL values to general population norms. METHODS: We conducted a cross-sectional study in 412 patients with CML. Data were collected by electronic survey. Three patient-reported outcomes questionnaires were used: EORTC QLQ-C30, EORTC QLQ-CML24 and EuroQol EQ-5D-3L. Health state utility values were computed using the French value set. We computed deviations from reference norms from the general population. We studied the determinants of health utility score using multiple regression models. RESULTS: The mean utility score (SD) was 0.72 (0.25) in the chronic phase and 0.84 (0.21) in treatment-free remission, with marked variations by gender. Patients with CML had a deviation from the reference norm of -0.15 on average (SD: 0.25). In terms of QoL, social functioning, role functioning and cognitive functioning were notably impacted with a mean difference of -16.0, -13.1 and -11.7 respectively. Fatigue, dyspnea and pain were the symptoms with the highest deviation from general population norms (mean difference of 20.6, 14.0 and 8.3 respectively). In the multiple regression analysis, fatigue was the most important independent predictor of the utility score. CONCLUSION: Although TKIs prevent the disease from progressing and even allow remission without treatment, QoL in patients with CML is notably altered. The utility scores deteriorate with CML symptoms. | |
| dc.description.sponsorship | Institut de Médecine Personnalisée du Cancer - ANR-10-IBHU-0001 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Chronic myeloid leukemia | |
| dc.subject.en | Quality of life | |
| dc.subject.en | Tyrosine kinase inhibitor | |
| dc.subject.en | Health utility score | |
| dc.title.en | Health state utility and quality of life measures in patients with chronic myeloid leukemia in France | |
| dc.title.alternative | Qual Life Res | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s11136-021-02794-5 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 33651280 | en_US |
| bordeaux.journal | Quality of Life Research | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | PharmacoEpi-Drugs | en_US |
| bordeaux.team | EPICENE_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03208632 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-26T14:48:00Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Quality%20of%20Life%20Research&rft.date=2021-03-02&rft.eissn=0962-9343&rft.issn=0962-9343&rft.au=FOULON,%20S&CONY-MAKHOUL,%20P&GUERCI-BRESLER,%20A&DABAN,%20M&KAPSO,%20R&rft.genre=article |
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||