Assessment Of Early Changes In Spectral Domain-Optical Coherence Tomography After Initiation Of Treatment With Intravitreal Aflibercept (Eylea) Over A 12-Week Period For Patients With Neovascular Age-Related Macular Degeneration: A Multicenter French Study (Start)
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | KOROBELNIK, Jean-Francois
ORCID: 0000-0002-4438-9535 IDREF: 028739272 | |
| dc.contributor.author | SOUIED, Eric H. | |
| dc.contributor.author | OUBRAHAM, Hassiba | |
| dc.contributor.author | RAZAVI, Sam | |
| dc.contributor.author | MAUGET-FAYSSE, Martine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SAVEL, Helene | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | CHENE, Genevieve | |
| dc.contributor.author | WOLF, Sebastian | |
| dc.date.accessioned | 2021-04-21T12:09:23Z | |
| dc.date.available | 2021-04-21T12:09:23Z | |
| dc.date.issued | 2021-03-01 | |
| dc.identifier.issn | 0275-004x | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/27008 | |
| dc.description.abstractEn | PURPOSE: To assess early changes in spectral-domain optical coherence tomography during the loading phase with intravitreal aflibercept therapy in patients with neovascular age-related macular degeneration. METHODS: In this prospective, open-label, single-arm, multicenter study, patients with neovascular age-related macular degeneration, who were antivascular endothelial growth factor treatment-naïve, received three monthly initial doses of intravitreal aflibercept 2 mg. The primary outcome was the proportion of patients with dry spectral-domain optical coherence tomography at 12 weeks, defined as an absence of intraretinal edema, intraretinal cysts, subretinal fluid, and subretinal pigment epithelium fluid. RESULTS: Fifty eyes of 50 patients were investigated. At 12 weeks, 34.0% (17/50) had dry spectral-domain optical coherence tomography. Marked reductions were observed for all other spectral-domain optical coherence tomography parameters. The mean macular central thickness fell significantly from 463.2 ± 184.3 µm at baseline to 288.9 ± 76.8 µm at Week 12 (P < 0.0001). The mean best-corrected visual acuity also improved significantly from 61.0 ± 16.0 letters at baseline to 66.6 ± 19.0 letters at Week 12 (P = 0.0006). CONCLUSION: The anatomic and functional outcomes improved over the 12-week study period. All outcome variables peaked after the third aflibercept injection, confirming the benefit of three initial doses. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Aflibercept | |
| dc.subject.en | Central retinal thickness | |
| dc.subject.en | Intravitreal injection | |
| dc.subject.en | Intraretinal edema | |
| dc.subject.en | Intraretinal cysts | |
| dc.subject.en | Neovascular age-related macular degeneration | |
| dc.subject.en | Retinal pigment epithelium | |
| dc.subject.en | Spectral-domain optical coherence tomography | |
| dc.subject.en | Subretinal fluid | |
| dc.title.en | Assessment Of Early Changes In Spectral Domain-Optical Coherence Tomography After Initiation Of Treatment With Intravitreal Aflibercept (Eylea) Over A 12-Week Period For Patients With Neovascular Age-Related Macular Degeneration: A Multicenter French Study (Start) | |
| dc.title.alternative | Retina | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1097/iae.0000000000002910 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 33600134 | en_US |
| bordeaux.journal | RETINA | en_US |
| bordeaux.page | 588-594 | en_US |
| bordeaux.volume | 41 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | USMR | en_US |
| bordeaux.team | MORPH3Eus | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03204317 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-21T12:09:27Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=RETINA&rft.date=2021-03-01&rft.volume=41&rft.issue=3&rft.spage=588-594&rft.epage=588-594&rft.eissn=0275-004x&rft.issn=0275-004x&rft.au=KOROBELNIK,%20Jean-Francois&SOUIED,%20Eric%20H.&OUBRAHAM,%20Hassiba&RAZAVI,%20Sam&MAUGET-FAYSSE,%20Martine&rft.genre=article |
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