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Clonal haematopoiesis and cardiovascular diseases: A growing relationship

dc.rights.licenseopenen_US
dc.contributor.authorFAWAZ, Sami
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorMANSIER, Olivier
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorPUCHEU, Yann
dc.contributor.authorMARTI, Séverine
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorLEROY, Harmony
dc.contributor.authorGAUFROY, Astrid
dc.contributor.authorBROITMAN, Jean
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorJAMES, Chloe
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorCOUFFINHAL, Thierry
dc.date.accessioned2021-03-24T15:30:13Z
dc.date.available2021-03-24T15:30:13Z
dc.date.issued2021-03-10
dc.identifier.issn1875-2128en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26799
dc.description.abstractEnCardiovascular diseases, particularly atherothrombosis, are the leading cause of death worldwide, but their mechanisms are not yet fully understood. Traditional cardiovascular risk factors have been known for many years, but are not enough to predict individual risk. Clonal haematopoiesis of indeterminate potential (CHIP) has been described recently; it corresponds to the clonal expansion of a population of haematopoietic cells in response to the acquisition of a somatic mutation, without any clinical or biological sign of haematological malignancy. The prevalence of this condition increases with age, reaching 10-20% of the general population aged>70 years. Recent observational studies have shown a link between CHIP and cardiovascular diseases in humans, revealing that CHIP carriers have a higher risk of myocardial infarction, heart failure and severe aortic valve stenosis. The prognosis of these conditions also seems to be altered by the presence of CHIP. Experimental studies have identified that the immune system and inflammation - particularly interleukin-1β-secreting macrophages - play a critical role in enhancing the cardiovascular consequences of CHIP, through their action on the atherosclerotic plaque and myocardial tissues. We aimed to write an extensive review of what is currently known about CHIP and its cardiovascular consequences, the pathophysiological mechanisms leading to the increased cardiovascular risk and, finally, the expected influence on our daily practice and how we care for patients with CHIP.
dc.language.isoENen_US
dc.title.enClonal haematopoiesis and cardiovascular diseases: A growing relationship
dc.title.alternativeArch Cardiovasc Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.acvd.2021.01.002en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie
dc.identifier.pubmed33714721en_US
bordeaux.journalArchives of cardiovascular diseasesen_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires - U1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
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