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27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium

dc.rights.licenseopenen_US
dc.contributor.authorWOLTERS, F. J.
dc.contributor.authorCHIBNIK, L. B.
dc.contributor.authorWAZIRY, R.
dc.contributor.authorANDERSON, R.
dc.contributor.authorBERR, C.
dc.contributor.authorBEISER, A.
dc.contributor.authorBIS, J. C.
dc.contributor.authorBLACKER, D.
dc.contributor.authorBOS, D.
dc.contributor.authorBRAYNE, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
dc.contributor.authorDARWEESH, S. K. L.
dc.contributor.authorDAVIS-PLOURDE, K. L.
dc.contributor.authorDE WOLF, F.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorFORNAGE, M.
dc.contributor.authorGOUDSMIT, J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGRASSET, Leslie
dc.contributor.authorGUDNASON, V.
dc.contributor.authorHADJICHRYSANTHOU, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorIKRAM, M. A.
dc.contributor.authorIKRAM, M. K.
dc.contributor.authorJOAS, E.
dc.contributor.authorKERN, S.
dc.contributor.authorKULLER, L. H.
dc.contributor.authorLAUNER, L.
dc.contributor.authorLOPEZ, O. L.
dc.contributor.authorMATTHEWS, F. E.
dc.contributor.authorMCRAE-MCKEE, K.
dc.contributor.authorMEIRELLES, O.
dc.contributor.authorMOSLEY, T. H., Jr.
dc.contributor.authorPASE, M. P.
dc.contributor.authorPSATY, B. M.
dc.contributor.authorSATIZABAL, C. L.
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorSKOOG, I.
dc.contributor.authorSTEPHAN, B. C. M.
dc.contributor.authorWETTERBERG, H.
dc.contributor.authorWONG, M. M.
dc.contributor.authorZETTERGREN, A.
dc.contributor.authorHOFMAN, A.
dc.date.accessioned2021-03-24T10:42:15Z
dc.date.available2021-03-24T10:42:15Z
dc.date.issued2020-08-04
dc.identifier.issn0028-3878en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26798
dc.description.abstractEnOBJECTIVE: To determine changes in the incidence of dementia between 1988 and 2015. METHODS: This analysis was performed in aggregated data from individuals >65 years in seven population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined non-overlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex. RESULTS: Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person years in individuals aged 65-69 years, to 65 per 1,000 person years for those aged 85-89 years. The incidence rate of dementia declined by 13% per calendar decade (95% CI: 7%-19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%-32%] versus 8% [0%-15%]). CONCLUSION: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations.
dc.description.sponsorshipCOGINUT : Cognition, anti-oxydants, acides gras: approche interdisciplinaire du rôle de la nutrition dans le vieillissement du cerveau - ANR-06-PNRA-0005en_US
dc.description.sponsorshipHistoire naturelle du déclin cognitif et du besoin de soins chez le sujet âgéen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.title.en27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium
dc.title.alternativeNeurologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1212/wnl.0000000000010022en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32611641en_US
dc.description.sponsorshipEuropeCommon mechanisms and pathways in Stroke and Alzheimer's disease.en_US
dc.description.sponsorshipEuropeVPH Dementia Research Enabled by ITen_US
bordeaux.journalNeurologyen_US
bordeaux.pagee519-e531en_US
bordeaux.volume95en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDMedical Research Councilen_US
bordeaux.identifier.funderIDNational Institutes of Healthen_US
bordeaux.identifier.funderIDDepartment of Health, Social Services and Public Safety, UK Governmenten_US
bordeaux.identifier.funderIDNational Heart, Lung, and Blood Instituteen_US
bordeaux.openAire.funderID667375 , 601055en_US
hal.identifierhal-03179365
hal.version1
hal.date.transferred2021-03-24T10:42:22Z
hal.exporttrue
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