A Comparison of Cell Activation, Exhaustion, and Expression of HIV Coreceptors and Restriction Factors in HIV-1-and HIV-2-Infected Nonprogressors
dc.rights.license | open | en_US |
dc.contributor.author | DIALLO, M. S. | |
dc.contributor.author | SAMRI, A. | |
dc.contributor.author | CHARPENTIER, C. | |
dc.contributor.author | BERTINE, M. | |
dc.contributor.author | CHEYNIER, R. | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | THIEBAUT, Rodolphe | |
dc.contributor.author | MATHERON, S. | |
dc.contributor.author | COLLIN, F. | |
dc.contributor.author | BRAIBANT, M. | |
dc.contributor.author | CANDOTTI, D. | |
dc.contributor.author | BRUN-VEZINET, F. | |
dc.contributor.author | AUTRAN, B. | |
dc.date.accessioned | 2021-03-16T13:18:02Z | |
dc.date.available | 2021-03-16T13:18:02Z | |
dc.date.issued | 2020-11-12 | |
dc.identifier.issn | 0889-2229 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26682 | |
dc.description.abstractEn | Human immunodeficiency viruses induce rare attenuated diseases due either to HIV-1 in the exceptional long-term nonprogressors (LTNPs) or to HIV-2 in West Africa. To better understand characteristics of these two disease types we performed a multiplex comparative analysis of cell activation, exhaustion, and expression of coreceptors and restriction factors in CD4 T cells susceptible to harbor those viruses. We analyzed by flow cytometry the expression of HLA-DR, PD1, CCR5, CXCR6, SAMHD1, Blimp-1, and TRIM5 alpha on CD4 T cell subsets from 10 HIV-1(+) LTNPs and 14 HIV-2(+) (12 nonprogressors and 2 progressors) of the ANRS CO-15 and CO-5 cohorts, respectively, and 12 HIV- healthy donors (HD). The V3 loop of the HIV-1 envelope from 6 HIV-1+ LTNPs was sequenced to determine the CXCR6-binding capacity. Proportions of HLA-DR+ and PD1+ cells were higher in memory CD4 T subsets from HIV-1 LTNPs compared with HIV-2 and HD. Similar findings were observed for CCR5+ cells although limited to central-memory CD4 T cell (TCM) and follicular helper T cell subsets, whereas all major subsets from HIV-1 LTNPs contained less CXCR6+ cells compared with HIV-2. All six V3 loop sequences from HIV-1 LTNPs contained a proline at position 326. Proportions of SAMHD1+ cells were higher in all resting CD4 T subsets from HIV-1 LTNPs compared with the other groups, whereas Blimp-1+ and Trim5 alpha+ cells did not differ. The CD4 T cell subsets from HIV-1 LTNPs differ from those of HIV-2-infected subjects by higher levels of activation, exhaustion, and SAMHD1 expression that can reflect the distinct patterns of host/virus relationships. | |
dc.language.iso | EN | en_US |
dc.title.en | A Comparison of Cell Activation, Exhaustion, and Expression of HIV Coreceptors and Restriction Factors in HIV-1-and HIV-2-Infected Nonprogressors | |
dc.title.alternative | AIDS Res Hum Retroviruses | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1089/aid.2020.0084 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 33050708 | en_US |
bordeaux.journal | AIDS Research and Human Retroviruses | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.team | SISTM_BPH | |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.export | false | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=AIDS%20Research%20and%20Human%20Retroviruses&rft.date=2020-11-12&rft.eissn=0889-2229&rft.issn=0889-2229&rft.au=DIALLO,%20M.%20S.&SAMRI,%20A.&CHARPENTIER,%20C.&BERTINE,%20M.&CHEYNIER,%20R.&rft.genre=article |
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