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Performance of Plasma Adenosine as a Biomarker for Predicting Cardiovascular Risk

dc.rights.licenseopenen_US
dc.contributor.authorSIMARD, T.
dc.contributor.authorJUNG, R. G.
dc.contributor.authorDI SANTO, P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAMIREZ, Daniel
dc.contributor.authorLABINAZ, A.
dc.contributor.authorGAUDET, C.
dc.contributor.authorMOTAZEDIAN, P.
dc.contributor.authorPARLOW, S.
dc.contributor.authorJOSEPH, J.
dc.contributor.authorMORELAND, R.
dc.contributor.authorMARBACH, J.
dc.contributor.authorBOLAND, P.
dc.contributor.authorPROMISLOW, S.
dc.contributor.authorRUSSO, J. J.
dc.contributor.authorCHONG, A. Y.
dc.contributor.authorSO, D.
dc.contributor.authorFROESCHL, M.
dc.contributor.authorLE MAY, M.
dc.contributor.authorHIBBERT, B.
dc.date.accessioned2021-03-11T13:34:17Z
dc.date.available2021-03-11T13:34:17Z
dc.date.issued2020-12-02
dc.identifier.issn1752-8062 (Electronic) 1752-8054 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26641
dc.description.abstractEnAdenosine boasts promising preclinical and clinical data supporting a vital role in modulating vascular homeostasis. Its widespread use as a diagnostic and therapeutic agent have been limited by its short half-life and complex biology, though adenosine-modulators have shown promise in improving vascular healing. Moreover, circulating adenosine has shown promise in predicting cardiovascular (CV) events. We sought to delineate whether circulating plasma adenosine levels predict CV events in patients undergoing invasive assessment for coronary artery disease. Patients undergoing invasive angiography had clinical data prospectively recorded in the Cardiovascular and Percutaneous ClInical TriALs (CAPITAL) revascularization registry and blood samples collected in the CAPITAL Biobank from which adenosine levels were quantified. Tertile-based analysis was used to assess prediction of major adverse cardiovascular events (MACE; composite of death, myocardial infarction, unplanned revascularization, and cerebrovascular accident). Secondary analyses included MACE subgroups, clinical subgroups and adenosine levels. There were 1,815 patients undergoing angiography who had blood collected with adenosine quantified in 1,323. Of those quantified, 51.0% were revascularized and 7.3% experienced MACE in 12 months of follow-up. Tertile-based analysis failed to demonstrate any stratification of MACE rates (log rank, P = 0.83), when comparing low-to-middle (hazard ratio (HR) 1.10, 95% confidence interval (CI) 0.68-1.78, P = 0.70) or low-to-high adenosine tertiles (HR 0.95, 95% CI 0.56-1.57, P = 0.84). In adjusted analysis, adenosine similarly failed to predict MACE. Finally, adenosine did not predict outcomes in patients with acute coronary syndrome nor in those revascularized or treated medically. Plasma adenosine levels do not predict subsequent CV outcomes or aid in patient risk stratification.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.title.enPerformance of Plasma Adenosine as a Biomarker for Predicting Cardiovascular Risk
dc.title.alternativeClin Transl Scien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/cts.12886en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33264483en_US
bordeaux.journalClin Transl Sci. / Clinical and translational scienceen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03166685
hal.version1
hal.date.transferred2021-03-11T13:34:22Z
hal.exporttrue
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