Reduced Intestinal Inflammation With Lumacaftor/Ivacaftor in Adolescents With Cystic Fibrosis
| dc.rights.license | open | en_US |
| dc.contributor.author | TETARD, Candice | |
| dc.contributor.author | MITTAINE, Marie | |
| dc.contributor.author | BUI, Stephanie | |
| dc.contributor.author | BEAUFILS, Fabien | |
| dc.contributor.author | MAUMUS, Pascale | |
| dc.contributor.author | FAYON, Michael | |
| dc.contributor.author | BURGEL, Pierre-Regis | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LAMIREAU, Thierry | |
| dc.contributor.author | DELHAES, Laurence | |
| dc.contributor.author | MAS, Emmanuel | |
| dc.contributor.author | ENAUD, Raphael | |
| dc.date.accessioned | 2021-03-11T13:02:22Z | |
| dc.date.available | 2021-03-11T13:02:22Z | |
| dc.date.issued | 2020-12 | |
| dc.identifier.issn | 1536-4801 (Electronic) 0277-2116 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26634 | |
| dc.description.abstractEn | A chronic intestinal inflammation may occur in patients with cystic fibrosis (CF), while no therapeutic management is proposed. Although Lumacaftor/Ivacaftor is well-known to modulate the defective cystic fibrosis transmembrane conductance regulator (CFTR) protein in lungs, no data are available on the impact of this treatment on CF intestinal disorders. We, therefore, investigated the evolution of intestinal inflammation after initiation of Lumacaftor/Ivacaftor in CF adolescents (median of follow-up: 336 days [IQR: 278;435]). Median fecal calprotectin concentrations decreased significantly after Lumacaftor/Ivacaftor initiation (102 ?g/g [IQR: 69-210]) compared with the baseline (713 ?g/g (IQR:148-852), P = 0.001). To our knowledge, this study showed for the first time that CF-related intestinal inflammation is improved by Lumacaftor/Ivacaftor treatment. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Reduced Intestinal Inflammation With Lumacaftor/Ivacaftor in Adolescents With Cystic Fibrosis | |
| dc.title.alternative | J Pediatr Gastroenterol Nutr | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1097/MPG.0000000000002864 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 32740537 | en_US |
| bordeaux.journal | Journal of Pediatric Gastroenterology and Nutrition | en_US |
| bordeaux.page | 778-781 | en_US |
| bordeaux.volume | 71 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | LEHA_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03166623 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-11T13:02:25Z | |
| hal.export | true | |
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