Short-term blood pressure variability, arterial stiffness, and cardiovascular events: results from the Bordeaux cohort
| dc.rights.license | open | en_US |
| dc.contributor.author | CREMER, A. | |
| dc.contributor.author | DOUBLET, J. | |
| dc.contributor.author | BOULESTREAU, R. | |
| dc.contributor.author | GAUDISSARD, J. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | TZOURIO, Christophe
IDREF: 69829209 | |
| dc.contributor.author | GOSSE, P. | |
| dc.date.accessioned | 2021-03-01T13:09:25Z | |
| dc.date.available | 2021-03-01T13:09:25Z | |
| dc.date.issued | 2021-01-07 | |
| dc.identifier.issn | 0263-6352 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26383 | |
| dc.description.abstractEn | OBJECTIVE: Short-term blood pressure variability derived from 24-h ambulatory monitoring is associated with poor cardiovascular prognosis. However, previous analyses of this have clearly been influenced by clinical cofounders, particularly blood pressure (BP) level. Arterial stiffness is a powerful marker of cardiovascular risk, which may influence BP variability. In this study, we assessed the prognostic value of BP variability based on 24-h ambulatory measurements and adjusted for arterial stiffness. METHODS: Population: Bordeaux cohort of hypertensive patients. Inclusion criteria were 24-h ambulatory BP monitoring at baseline with measurements every 15' day and night, determination of wake-up time and bedtime, and assessment of arterial stiffness with monitoring of Korotkoff sound arrival time. A total of 969 patients (age 54 ± 14 years) with an average follow up of 120 ± 78 months and 178 cardiovascular recorded events were included. RESULTS: In univariate survival analyses, the standard deviations of day, night, and 24-h SBP were associated with the occurrence of cardiovascular events. The standard deviation of night-time SBP showed the strongest association with the outcome variable and was entered into multivariate analyses. In multivariate analyses, night-time SBP variability remained significantly associated with the occurrence of cardiovascular events after adjusting for major cardiovascular risk factors, 24-h SBP, and arterial stiffness. BP variability and arterial stiffness showed no significant association. CONCLUSION: Our results suggest that variability of night-time SBP is an important marker of the risk of cardiovascular events in hypertensive patients, independently of average 24-h BP and arterial stiffness. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Short-term blood pressure variability, arterial stiffness, and cardiovascular events: results from the Bordeaux cohort | |
| dc.title.alternative | J Hypertens | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1097/hjh.0000000000002735 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 33427788 | en_US |
| bordeaux.journal | Journal of Hypertension | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | HEALTHY_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03154964 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-01T13:09:28Z | |
| hal.export | true | |
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