Association of Plasma Soluble Vascular Cell Adhesion Molecule-1 and sCD14 With Mortality in HIV-1-Infected West African Adults With High CD4 Counts
| dc.rights.license | open | en_US |
| dc.contributor.author | AFFI, R. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GABILLARD, Delphine | |
| dc.contributor.author | DUNYACH-REMY, C. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | NTAKPE, Jean-Baptiste | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MOH, Desmorys Raoul | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BADJE, Anani Dodzi | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | KOUAME, Menan Gerard | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | KARCHER, Sophie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LE CARROU, Jérôme | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DANEL, Christine | |
| dc.contributor.author | CHEVALIER, M. F. | |
| dc.contributor.author | ROUZIOUX, C. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | EHOLIE, Serge P. | |
| dc.contributor.author | LAVIGNE, J. P. | |
| dc.contributor.author | INWOLEY, A. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ANGLARET, Xavier | |
| dc.contributor.author | WEISS, L. | |
| dc.date.accessioned | 2021-03-01T08:24:45Z | |
| dc.date.available | 2021-03-01T08:24:45Z | |
| dc.date.issued | 2021-01-01 | |
| dc.identifier.issn | 1944-7884 (Electronic) 1525-4135 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26367 | |
| dc.description.abstractEn | BACKGROUND: Several biomarkers of inflammation and coagulation were reported to be associated with HIV disease progression in different settings. Here we report the association between eleven biomarkers and medium-term mortality in HIV-infected West Africa adults. METHODS: In Temprano ANRS 12136, ART-naïve HIV-infected adults with high CD4 counts were randomly assigned either to start ART immediately or defer ART until the WHO criteria were met. Participants who completed the 30-month trial follow-up were invited to participate in a post-trial phase (PTP). The PTP endpoint was all-cause death. We used multivariate Cox proportional models to analyze the association between baseline plasma biomarkers (IL-1ra, IL-6, sVCAM-1, sCD14, D-dimer, Fibrinogen, IP-10, sCD163, albumin, hsCRP, 16S rDNA) and all-cause death in the Temprano participants randomized to defer ART. RESULTS: 477 patients (median age 35, 78% women, median CD4 count: 379 cells/mm) were randomly assigned to defer starting ART until the WHO criteria were met. The participants were followed for 2646 person-years (median 5.8 years). In the follow-up, 89% of participants started ART and 30 died. In the multivariate analysis adjusted for the study center, sex, baseline CD4 count, isoniazid preventive therapy, plasma HIV-1 RNA, PBMC HIV-1 DNA and ART, the risk of death was significantly associated with baseline sVCAM-1 (≥ 1458 vs. < 1458: adjusted hazard ratio [aHR] 2.57, 95% CI 1.13-5.82) and sCD14 (≥ 2187 vs. < 2187: aHR 2.79, IQR 1.29-6.02) levels. CONCLUSION: In these sub-Saharan African adults with high CD4 counts, pre-ART plasma sVCAM-1 and sCD14 levels were independently associated with mortality. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Association of Plasma Soluble Vascular Cell Adhesion Molecule-1 and sCD14 With Mortality in HIV-1-Infected West African Adults With High CD4 Counts | |
| dc.title.alternative | J Acquir Immune Defic Syndr | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1097/qai.0000000000002533 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| bordeaux.journal | Journal of Acquired Immune Deficiency Syndromes | en_US |
| bordeaux.page | 138-145 | en_US |
| bordeaux.volume | 86 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | IDLIC | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03165510 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-10T15:40:22Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Acquired%20Immune%20Deficiency%20Syndromes&rft.date=2021-01-01&rft.volume=86&rft.issue=1&rft.spage=138-145&rft.epage=138-145&rft.eissn=1944-7884%20(Electronic)%201525-4135%20(Linking)&rft.issn=1944-7884%20(Electronic)%201525-4135%20(Linking)&rft.au=AFFI,%20R.&GABILLARD,%20Delphine&DUNYACH-REMY,%20C.&NTAKPE,%20Jean-Baptiste&MOH,%20Desmorys%20Raoul&rft.genre=article |
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