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Cervical cancer risk in women living with HIV across four continents: A multicohort study

dc.rights.licenseopenen_US
dc.contributor.authorROHNER, E.
dc.contributor.authorBUTIKOFER, L.
dc.contributor.authorSCHMIDLIN, K.
dc.contributor.authorSENGAYI, M.
dc.contributor.authorMASKEW, M.
dc.contributor.authorGIDDY, J.
dc.contributor.authorTAGHAVI, K.
dc.contributor.authorMOORE, R. D.
dc.contributor.authorGOEDERT, J. J.
dc.contributor.authorGILL, M. J.
dc.contributor.authorSILVERBERG, M. J.
dc.contributor.authorD'SOUZA, G.
dc.contributor.authorPATEL, P.
dc.contributor.authorCASTILHO, J. L.
dc.contributor.authorROSS, J.
dc.contributor.authorSOHN, A.
dc.contributor.authorBANI-SADR, F.
dc.contributor.authorTAYLOR, N.
dc.contributor.authorPAPARIZOS, V.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorVERBON, A.
dc.contributor.authorVEHRESCHILD, J. J.
dc.contributor.authorPOST, F. A.
dc.contributor.authorSABIN, C.
dc.contributor.authorMOCROFT, A.
dc.contributor.authorDRONDA, F.
dc.contributor.authorOBEL, N.
dc.contributor.authorGRABAR, S.
dc.contributor.authorSPAGNUOLO, V.
dc.contributor.authorQUIROS-ROLDAN, E.
dc.contributor.authorMUSSINI, C.
dc.contributor.authorMIRO, J. M.
dc.contributor.authorMEYER, L.
dc.contributor.authorHASSE, B.
dc.contributor.authorKONOPNICKI, D.
dc.contributor.authorROCA, B.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBARGER, Diana
dc.contributor.authorCLIFFORD, G. M.
dc.contributor.authorFRANCESCHI, S.
dc.contributor.authorEGGER, M.
dc.contributor.authorBOHLIUS, J.
dc.date.accessioned2021-02-25T14:05:00Z
dc.date.available2021-02-25T14:05:00Z
dc.date.issued2020
dc.identifier.issn1097-0215 (Electronic) 0020-7136 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26356
dc.description.abstractEnWe compared invasive cervical cancer (ICC) incidence rates in Europe, South Africa, Latin and North America among women living with HIV who initiated antiretroviral therapy (ART) between 1996 and 2014. We analyzed cohort data from the International Epidemiology Databases to Evaluate AIDS (IeDEA) and the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord. We used flexible parametric survival models to determine regional ICC rates and risk factors for incident ICC. We included 64,231 women from 45 countries. During 320,141 person‐years (pys), 356 incident ICC cases were diagnosed (Europe 164, South Africa 156, North America 19 and Latin America 17). Raw ICC incidence rates per 100,000 pys were 447 in South Africa (95% confidence interval [CI]: 382–523), 136 in Latin America (95% CI: 85–219), 76 in North America (95% CI: 48–119) and 66 in Europe (95% CI: 57–77). Compared to European women ICC rates at 5 years after ART initiation were more than double in Latin America (adjusted hazard ratio [aHR]: 2.43, 95% CI: 1.27–4.68) and 11 times higher in South Africa (aHR: 10.66, 95% CI: 6.73–16.88), but similar in North America (aHR: 0.79, 95% CI: 0.37–1.71). Overall, ICC rates increased with age (>50 years vs. 16–30 years, aHR: 1.57, 95% CI: 1.03–2.40) and lower CD4 cell counts at ART initiation (per 100 cell/μl decrease, aHR: 1.25, 95% CI: 1.15–1.36). Improving access to early ART initiation and effective cervical cancer screening in women living with HIV should be key parts of global efforts to reduce cancer‐related health inequities.
dc.language.isoENen_US
dc.subjectIDLIC
dc.title.enCervical cancer risk in women living with HIV across four continents: A multicohort study
dc.title.alternativeInt J Canceren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/ijc.32260en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31215037en_US
bordeaux.journalInternational Journal of Canceren_US
bordeaux.page601-609en_US
bordeaux.volume146en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamIDLICen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03152338
hal.version1
hal.date.transferred2021-02-25T14:05:06Z
hal.exporttrue
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