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Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia

dc.rights.licenseopenen_US
dc.contributor.authorLEE, C. M.
dc.contributor.authorWOODWARD, M.
dc.contributor.authorBATTY, G. D.
dc.contributor.authorBEISER, A. S.
dc.contributor.authorBELL, S.
dc.contributor.authorBERR, C.
dc.contributor.authorBJERTNESS, E.
dc.contributor.authorCHALMERS, J.
dc.contributor.authorCLARKE, R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
dc.contributor.authorDAVIS-PLOURDE, K.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDI ANGELANTONIO, E.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFEART-COURET, Catherine
ORCID: 0000-0002-7959-1610
IDREF: 08195848X
dc.contributor.authorFRIKKE-SCHMIDT, R.
dc.contributor.authorGREGSON, J.
dc.contributor.authorHAAN, M. N.
dc.contributor.authorHASSING, L. B.
dc.contributor.authorHAYDEN, K. M.
dc.contributor.authorHOEVENAAR-BLOM, M. P.
dc.contributor.authorKAPRIO, J.
dc.contributor.authorKIVIMAKI, M.
dc.contributor.authorLAPPAS, G.
dc.contributor.authorLARSON, E. B.
dc.contributor.authorLEBLANC, E. S.
dc.contributor.authorLEE, A.
dc.contributor.authorLUI, L. Y.
dc.contributor.authorMOLL VAN CHARANTE, E. P.
dc.contributor.authorNINOMIYA, T.
dc.contributor.authorNORDESTGAARD, L. T.
dc.contributor.authorOHARA, T.
dc.contributor.authorOHKUMA, T.
dc.contributor.authorPALVIAINEN, T.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPERES, Karine
ORCID: 0000-0002-0720-0684
IDREF: 080634001
dc.contributor.authorPETERS, R.
dc.contributor.authorQIZILBASH, N.
dc.contributor.authorRICHARD, E.
dc.contributor.authorROSENGREN, A.
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorSHIPLEY, M.
dc.contributor.authorSINGH-MANOUX, A.
dc.contributor.authorSTRAND, B. H.
dc.contributor.authorVAN GOOL, W. A.
dc.contributor.authorVUOKSIMAA, E.
dc.contributor.authorYAFFE, K.
dc.contributor.authorHUXLEY, R. R.
dc.date.accessioned2021-02-24T10:54:59Z
dc.date.available2021-02-24T10:54:59Z
dc.date.issued2020
dc.identifier.issn1467-789X (Electronic) 1467-7881 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26340
dc.description.abstractEnUncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circumference, and annual percent weight change with risk of dementia and its subtypes by pooling data from 19 prospective cohort studies and four clinical trials using meta‐analysis. Compared with body mass index–defined lower‐normal weight (18.5‐22.4 kg/m2), the risk of all‐cause dementia was higher among underweight individuals but lower among those with upper‐normal (22.5‐24.9 kg/m2) levels. Obesity was associated with higher risk in vascular dementia. Similarly, relative to the lowest fifth of waist circumference, those in the highest fifth had nonsignificant higher vascular dementia risk. Weight loss was associated with higher all‐cause dementia risk relative to weight maintenance. Weight gain was weakly associated with higher vascular dementia risk. The relationship between body size, weight change, and dementia is complex and exhibits non‐linear associations depending on dementia subtype under scrutiny. Weight loss was associated with an elevated risk most likely due to reverse causality and/or pathophysiological changes in the brain, although the latter remains speculative.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectSEPIA
dc.subjectVINTAGE
dc.subjectLEHA
dc.title.enAssociation of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia
dc.title.alternativeObes Reven_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/obr.12989en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31898862en_US
bordeaux.journalObesity Reviewsen_US
bordeaux.pagee12989en_US
bordeaux.volume21en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.teamVINTAGEen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03150959
hal.version1
hal.date.transferred2021-02-24T10:59:00Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Obesity%20Reviews&rft.date=2020&rft.volume=21&rft.issue=4&rft.spage=e12989&rft.epage=e12989&rft.eissn=1467-789X%20(Electronic)%201467-7881%20(Linking)&rft.issn=1467-789X%20(Electronic)%201467-7881%20(Linking)&rft.au=LEE,%20C.%20M.&WOODWARD,%20M.&BATTY,%20G.%20D.&BEISER,%20A.%20S.&BELL,%20S.&rft.genre=article


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