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PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment

dc.rights.licenseopenen_US
dc.contributor.authorKLEINEIDAM, L.
dc.contributor.authorCHOURAKI, V.
dc.contributor.authorPROCHNICKI, T.
dc.contributor.authorVAN DER LEE, S. J.
dc.contributor.authorMADRID-MARQUEZ, L.
dc.contributor.authorWAGNER-THELEN, H.
dc.contributor.authorKARACA, I.
dc.contributor.authorWEINHOLD, L.
dc.contributor.authorWOLFSGRUBER, S.
dc.contributor.authorBOLAND, A.
dc.contributor.authorMARTINO ADAMI, P. V.
dc.contributor.authorLEWCZUK, P.
dc.contributor.authorPOPP, J.
dc.contributor.authorBROSSERON, F.
dc.contributor.authorJANSEN, I. E.
dc.contributor.authorHULSMAN, M.
dc.contributor.authorKORNHUBER, J.
dc.contributor.authorPETERS, O.
dc.contributor.authorBERR, C.
dc.contributor.authorHEUN, R.
dc.contributor.authorFROLICH, L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
dc.contributor.authorHULL, M.
dc.contributor.authorESPINOSA, A.
dc.contributor.authorHERNANDEZ, I.
dc.contributor.authorDE ROJAS, I.
dc.contributor.authorORELLANA, A.
dc.contributor.authorVALERO, S.
dc.contributor.authorSTRINGA, N.
dc.contributor.authorVAN SCHOOR, N. M.
dc.contributor.authorHUISMAN, M.
dc.contributor.authorSCHELTENS, P.
dc.contributor.authorALZHEIMER'S DISEASE NEUROIMAGING, Initiative
dc.contributor.authorRUTHER, E.
dc.contributor.authorDELEUZE, J. F.
dc.contributor.authorWILTFANG, J.
dc.contributor.authorTARRAGA, L.
dc.contributor.authorSCHMID, M.
dc.contributor.authorSCHERER, M.
dc.contributor.authorRIEDEL-HELLER, S.
dc.contributor.authorHENEKA, M. T.
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorJESSEN, F.
dc.contributor.authorBOADA, M.
dc.contributor.authorMAIER, W.
dc.contributor.authorSCHNEIDER, A.
dc.contributor.authorGONZALEZ-PEREZ, A.
dc.contributor.authorVAN DER FLIER, W. M.
dc.contributor.authorWAGNER, M.
dc.contributor.authorLAMBERT, J. C.
dc.contributor.authorHOLSTEGE, H.
dc.contributor.authorSAEZ, M. E.
dc.contributor.authorLATZ, E.
dc.contributor.authorRUIZ, A.
dc.contributor.authorRAMIREZ, A.
dc.date.accessioned2021-02-24T10:37:37Z
dc.date.available2021-02-24T10:37:37Z
dc.date.issued2020
dc.identifier.issn1432-0533 (Electronic) 0001-6322 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26338
dc.description.abstractEnpinnings, we identified a network of co-expressed proteins connecting PLCG2 to APOE and TREM2 using unsupervised co-regulatory network analysis. The network was highly enriched for the complement cascade and genes differentially expressed in disease-associated microglia. Our data show that p.P522R in PLCG2 reduces AD disease progression by mitigating tau pathology in the presence of amyloid pathology and, as a consequence, maintains cognitive function. Targeting the enzyme PLCG2 might provide a new therapeutic approach for treating AD.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectSEPIA
dc.subjectHEALTHY
dc.title.enPLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment
dc.title.alternativeActa Neuropatholen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00401-020-02138-6en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32166339en_US
bordeaux.journalActa Neuropathologicaen_US
bordeaux.page1025-1044en_US
bordeaux.volume139en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.teamHEALTHY_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03150932
hal.version1
hal.date.transferred2021-02-24T10:37:44Z
hal.exporttrue
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