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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

dc.rights.licenseopenen_US
dc.contributor.authorHOFER, E.
dc.contributor.authorROSHCHUPKIN, G. V.
dc.contributor.authorADAMS, H. H. H.
dc.contributor.authorKNOL, M. J.
dc.contributor.authorLIN, H.
dc.contributor.authorLI, S.
dc.contributor.authorZARE, H.
dc.contributor.authorAHMAD, S.
dc.contributor.authorARMSTRONG, N. J.
dc.contributor.authorSATIZABAL, C. L.
dc.contributor.authorBERNARD, M.
dc.contributor.authorBIS, J. C.
dc.contributor.authorGILLESPIE, N. A.
dc.contributor.authorLUCIANO, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMISHRA, Aniket
dc.contributor.authorSCHOLZ, M.
dc.contributor.authorTEUMER, A.
dc.contributor.authorXIA, R.
dc.contributor.authorJIAN, X.
dc.contributor.authorMOSLEY, T. H.
dc.contributor.authorSABA, Y.
dc.contributor.authorPIRPAMER, L.
dc.contributor.authorSEILER, S.
dc.contributor.authorBECKER, J. T.
dc.contributor.authorCARMICHAEL, O.
dc.contributor.authorROTTER, J. I.
dc.contributor.authorPSATY, B. M.
dc.contributor.authorLOPEZ, O. L.
dc.contributor.authorAMIN, N.
dc.contributor.authorVAN DER LEE, S. J.
dc.contributor.authorYANG, Q.
dc.contributor.authorHIMALI, J. J.
dc.contributor.authorMAILLARD, P.
dc.contributor.authorBEISER, A. S.
dc.contributor.authorDECARLI, C.
dc.contributor.authorKARAMA, S.
dc.contributor.authorLEWIS, L.
dc.contributor.authorHARRIS, M.
dc.contributor.authorBASTIN, M. E.
dc.contributor.authorDEARY, I. J.
dc.contributor.authorVERONICA WITTE, A.
dc.contributor.authorBEYER, F.
dc.contributor.authorLOEFFLER, M.
dc.contributor.authorMATHER, K. A.
dc.contributor.authorSCHOFIELD, P. R.
dc.contributor.authorTHALAMUTHU, A.
dc.contributor.authorKWOK, J. B.
dc.contributor.authorWRIGHT, M. J.
dc.contributor.authorAMES, D.
dc.contributor.authorTROLLOR, J.
dc.contributor.authorJIANG, J.
dc.contributor.authorBRODATY, H.
dc.contributor.authorWEN, W.
dc.contributor.authorVERNOOIJ, M. W.
dc.contributor.authorHOFMAN, A.
dc.contributor.authorUITTERLINDEN, A. G.
dc.contributor.authorNIESSEN, W. J.
dc.contributor.authorWITTFELD, K.
dc.contributor.authorBÜLOW, R.
dc.contributor.authorVÖLKER, U.
dc.contributor.authorPAUSOVA, Z.
dc.contributor.authorBRUCE PIKE, G.
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorMAINGAULT, Sophie
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorCRIVELLO, Fabrice
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorAMOUYEL, Philippe
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
hal.structure.identifierGroupe d'imagerie neurofonctionnelle [GIN]
dc.contributor.authorMAZOYER, Bernard
dc.contributor.authorNEALE, M. C.
dc.contributor.authorFRANZ, C. E.
dc.contributor.authorLYONS, M. J.
dc.contributor.authorPANIZZON, M. S.
dc.contributor.authorANDREASSEN, O. A.
dc.contributor.authorDALE, A. M.
dc.contributor.authorLOGUE, M.
dc.contributor.authorGRASBY, K. L.
dc.contributor.authorJAHANSHAD, N.
dc.contributor.authorPAINTER, J. N.
dc.contributor.authorCOLODRO-CONDE, L.
dc.contributor.authorBRALTEN, J.
dc.contributor.authorHIBAR, D. P.
dc.contributor.authorLIND, P. A.
dc.contributor.authorPIZZAGALLI, F.
dc.contributor.authorSTEIN, J. L.
dc.contributor.authorTHOMPSON, P. M.
dc.contributor.authorMEDLAND, S. E.
dc.contributor.authorSACHDEV, P. S.
dc.contributor.authorKREMEN, W. S.
dc.contributor.authorWARDLAW, J. M.
dc.contributor.authorVILLRINGER, A.
dc.contributor.authorVAN DUIJN, C. M.
dc.contributor.authorGRABE, H. J.
dc.contributor.authorLONGSTRETH, Jr., W. T.
dc.contributor.authorFORNAGE, M.
dc.contributor.authorPAUS, T.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorARFAN IKRAM, M.
dc.contributor.authorSCHMIDT, H.
dc.contributor.authorSCHMIDT, R.
dc.contributor.authorSESHADRI, Sudha
dc.date.accessioned2021-02-23T15:35:27Z
dc.date.available2021-02-23T15:35:27Z
dc.date.issued2020
dc.identifier.issn2041-1723 (Electronic) 2041-1723 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26333
dc.description.abstractEnCortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectHEALTHY
dc.subjectVINTAGE
dc.title.enGenetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
dc.title.alternativeNat Communen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-020-18367-yen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32963231en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page4796en_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03150306
hal.version1
hal.date.transferred2021-02-23T15:35:41Z
hal.exporttrue
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