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International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium

dc.rights.licenseopenen_US
dc.contributor.authorBRAT, G. A.
dc.contributor.authorWEBER, G. M.
dc.contributor.authorGEHLENBORG, N.
dc.contributor.authorAVILLACH, P.
dc.contributor.authorPALMER, N. P.
dc.contributor.authorCHIOVATO, L.
dc.contributor.authorCIMINO, J.
dc.contributor.authorWAITMAN, L. R.
dc.contributor.authorOMENN, G. S.
dc.contributor.authorMALOVINI, A.
dc.contributor.authorMOORE, J. H.
dc.contributor.authorBEAULIEU-JONES, B. K.
dc.contributor.authorTIBOLLO, V.
dc.contributor.authorMURPHY, S. N.
dc.contributor.authorYI, S. L.
dc.contributor.authorKELLER, M. S.
dc.contributor.authorBELLAZZINI, R.
dc.contributor.authorHANAUER, D. A.
dc.contributor.authorSERRET-LARMANDE, A.
dc.contributor.authorGUTIERREZ-SACRISTAN, A.
dc.contributor.authorHOLMES, J. J.
dc.contributor.authorBELL, D. S.
dc.contributor.authorMANDL, K. D.
dc.contributor.authorFOLLETT, R. W.
dc.contributor.authorKLANN, J. G.
dc.contributor.authorMURAD, D. A.
dc.contributor.authorSCUDELLER, L.
dc.contributor.authorBUCALO, M.
dc.contributor.authorKIRCHOFF, K.
dc.contributor.authorCRAIG, J.
dc.contributor.authorOBEID, J.
dc.contributor.authorJOUHET, Vianney
dc.contributor.authorGRIFFIER, Romain
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOSSIN, Sebastien
dc.contributor.authorMOAL, B.
dc.contributor.authorPATEL, L. P.
dc.contributor.authorBELLASI, A.
dc.contributor.authorPROKOSCH, H. U.
dc.contributor.authorKRASKA, D.
dc.contributor.authorSLIZ, P.
dc.contributor.authorTAN, A. L. M.
dc.contributor.authorNGIAM, K. Y.
dc.contributor.authorZAMBELLI, A.
dc.contributor.authorMOWERY, D. L.
dc.contributor.authorSCHIVER, E.
dc.contributor.authorDEVKOTA, B.
dc.contributor.authorBRADFORD, R. L.
dc.contributor.authorDANIAR, M.
dc.contributor.authorDANIEL, C.
dc.contributor.authorBENOIT, V.
dc.contributor.authorBEY, R.
dc.contributor.authorPARIS, N.
dc.contributor.authorSERRE, P.
dc.contributor.authorORLOVA, N.
dc.contributor.authorDUBIEL, J.
dc.contributor.authorHILKA, M.
dc.contributor.authorJANNOT, A. S.
dc.contributor.authorBREANT, S.
dc.contributor.authorLEBLANC, J.
dc.contributor.authorGRIFFON, N.
dc.contributor.authorBURGUN, A.
dc.contributor.authorBERNAUX, M.
dc.contributor.authorSANDRIN, A.
dc.contributor.authorSALAMANCA, E.
dc.contributor.authorCORMONT, S.
dc.contributor.authorGANSLANDT, T.
dc.contributor.authorGRADINGER, T.
dc.contributor.authorCHAMP, J.
dc.contributor.authorBOEKER, M.
dc.contributor.authorMARTEL, P.
dc.contributor.authorESTEVE, L.
dc.contributor.authorGRAMFORT, A.
dc.contributor.authorGRISEL, O.
dc.contributor.authorLEPROVOST, D.
dc.contributor.authorMOREAU, T.
dc.contributor.authorVAROQUAUX, G.
dc.contributor.authorVIE, J. J.
dc.contributor.authorWASSERMANN, D.
dc.contributor.authorMENSCH, A.
dc.contributor.authorCAUCHETEUX, C.
dc.contributor.authorHAVERKAMP, C.
dc.contributor.authorLEMAITRE, G.
dc.contributor.authorBOSARI, S.
dc.contributor.authorKRANTZ, I. D.
dc.contributor.authorSOUTH, A.
dc.contributor.authorCAI, T.
dc.contributor.authorKOHANE, I. S.
dc.date.accessioned2021-02-23T15:04:06Z
dc.date.available2021-02-23T15:04:06Z
dc.date.issued2020
dc.identifier.issn2398-6352en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26330
dc.description.abstractEnWe leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across five countries (www.covidclinical.net). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectERIAS
dc.title.enInternational electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium
dc.title.alternativeNPJ Digit Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41746-020-00308-0en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalnpj Digital Medicineen_US
bordeaux.page109en_US
bordeaux.volume3en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamERIASen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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