Long-Term Trajectories of Body Weight, Diet, and Physical Activity From Midlife Through Late Life and Subsequent Cognitive Decline in Women
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | WAGNER, Maud | |
| dc.contributor.author | GRODSTEIN, F. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PROUST LIMA, Cecile
ORCID: 0000-0002-9884-955X IDREF: 114375747 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SAMIERI, Cecilia | |
| dc.date.accessioned | 2021-02-22T15:33:03Z | |
| dc.date.available | 2021-02-22T15:33:03Z | |
| dc.date.issued | 2020 | |
| dc.identifier.issn | 0002-9262 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26316 | |
| dc.description.abstractEn | Healthy lifestyles are promising targets for prevention of cognitive aging, yet the optimal time windows for interventions remain unclear. We selected a case-control sample nested within the Nurses’ Health Study (starting year 1976, mean age = 51 years), including 14,956 women aged ≥70 years who were free of both stroke and cognitive impairment at enrollment in a cognitive substudy (1995–2001). Cases (n = 1,496) were women with the 10% worst slopes of cognitive decline, and controls (n = 7,478) were those with slopes better than the median. We compared the trajectories of body mass index (weight (kg)/height (m)2), alternate Mediterranean diet (A-MeDi) score, and physical activity between groups, from midlife through 1 year preceding the cognitive substudy. In midlife, cases had higher body mass index than controls (mean difference (MD) = 0.59 units, 95% confidence interval (CI): 0.39, 0.80), lower physical activity (MD = –1.41 metabolic equivalent of task–hours/week, 95% CI: –2.07, –0.71), and worse A-MeDi scores (MD = –0.16 points, 95% CI: –0.26, –0.06). From midlife through later life, compared with controls, cases had consistently lower A-MeDi scores but a deceleration of weight gain and a faster decrease in physical activity. In conclusion, maintaining a healthy lifestyle since midlife may help reduce cognitive decline in aging. At older ages, both deceleration of weight gain and a decrease in physical activity may reflect early signs of cognitive impairment. | |
| dc.language.iso | EN | en_US |
| dc.subject | Biostatistics | |
| dc.subject | LEHA | |
| dc.title.en | Long-Term Trajectories of Body Weight, Diet, and Physical Activity From Midlife Through Late Life and Subsequent Cognitive Decline in Women | |
| dc.title.alternative | Am J Epidemiol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/aje/kwz262 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 31781745 | en_US |
| bordeaux.journal | American Journal of Epidemiology | en_US |
| bordeaux.page | 305-313 | en_US |
| bordeaux.volume | 189 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | BIOSTAT_BPH | en_US |
| bordeaux.team | LEHA_BPH | |
| bordeaux.team | LEHA_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03148984 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-02-22T15:33:07Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American%20Journal%20of%20Epidemiology&rft.date=2020&rft.volume=189&rft.issue=4&rft.spage=305-313&rft.epage=305-313&rft.eissn=0002-9262&rft.issn=0002-9262&rft.au=WAGNER,%20Maud&GRODSTEIN,%20F.&PROUST%20LIMA,%20Cecile&SAMIERI,%20Cecilia&rft.genre=article |
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