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Mortality Among People With HIV Treated for Tuberculosis Based on Positive, Negative, or No Bacteriologic Test Results for Tuberculosis: The IeDEA Consortium

dc.rights.licenseopenen_US
dc.contributor.authorHUMPHREY, J. M.
dc.contributor.authorMPOFU, P.
dc.contributor.authorPETTIT, A. C.
dc.contributor.authorMUSICK, B.
dc.contributor.authorCARTER, E. J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMESSOU, Eugene
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMARCY, Olivier
dc.contributor.authorCRABTREE-RAMIREZ, B.
dc.contributor.authorYOTEBIENG, M.
dc.contributor.authorANASTOS, K.
dc.contributor.authorSTERLING, T. R.
dc.contributor.authorYIANNOUTSOS, C.
dc.contributor.authorDIERO, L.
dc.contributor.authorWOOLS-KALOUSTIAN, K.
dc.date.accessioned2021-01-26T15:09:05Z
dc.date.available2021-01-26T15:09:05Z
dc.date.issued2020
dc.identifier.issn2328-8957 (Print) 2328-8957en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26034
dc.description.abstractEnBackground In resource-constrained settings, many people with HIV (PWH) are treated for tuberculosis (TB) without bacteriologic testing. Their mortality compared with those with bacteriologic testing is uncertain. Methods We conducted an observational cohort study among PWH ≥15 years of age initiating TB treatment at sites affiliated with 4 International epidemiology Databases to Evaluate AIDS consortium regions from 2012 to 2014: Caribbean, Central and South America, and Central, East, and West Africa. The exposure of interest was the TB bacteriologic test status at TB treatment initiation: positive, negative, or no test result. The hazard of death in the 12 months after TB treatment initiation was estimated using a Cox proportional hazard model. Missing covariate values were multiply imputed. Results In 2091 PWH, median age 36 years, 53% had CD4 counts ≤200 cells/mm3, and 52% were on antiretroviral therapy (ART) at TB treatment initiation. The adjusted hazard of death was higher in patients with no test compared with those with positive test results (hazard ratio [HR], 1.56; 95% confidence interval [CI], 1.08–2.26). The hazard of death was also higher among those with negative compared with positive tests but was not statistically significant (HR, 1.28; 95% CI, 0.91–1.81). Being on ART, having a higher CD4 count, and tertiary facility level were associated with a lower hazard for death. Conclusions There was some evidence that PWH treated for TB with no bacteriologic test results were at higher risk of death than those with positive tests. Research is needed to understand the causes of death in PWH treated for TB without bacteriologic testing.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectIDLIC
dc.title.enMortality Among People With HIV Treated for Tuberculosis Based on Positive, Negative, or No Bacteriologic Test Results for Tuberculosis: The IeDEA Consortium
dc.title.alternativeOpen Forum Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ofid/ofaa006en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalOpen Forum Infectious Diseasesen_US
bordeaux.pageofaa006en_US
bordeaux.volume7en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamIDLICen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03121839
hal.version1
hal.date.transferred2021-01-26T15:09:10Z
hal.exporttrue
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