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Refined carbohydrate-rich diet is associated with long-term risk of dementia and Alzheimer's disease in apolipoprotein E epsilon4 allele carriers

dc.rights.licenseopenen_US
dc.contributor.authorGENTREAU, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHUY, Virginie
IDREF: 234159758
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFEART-COURET, Catherine
ORCID: 0000-0002-7959-1610
IDREF: 08195848X
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorRITCHIE, K.
dc.contributor.authorRAYMOND, M.
dc.contributor.authorBERTICAT, C.
dc.contributor.authorARTERO, S.
dc.date.accessioned2021-01-26T12:35:26Z
dc.date.available2021-01-26T12:35:26Z
dc.date.issued2020
dc.identifier.issn1552-5279 (Electronic) 1552-5260 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26011
dc.description.abstractEnIntroduction In animal models, refined carbohydrates (RF) worsen Alzheimer's disease (AD). However, the long‐term effects of high RF intake on the risk of dementia and AD are poorly described in epidemiological studies. Moreover, the interaction between RF and the apolipoprotein E ε4 allele (APOE‐ε4) is unknown. Our study investigated whether RF‐rich diets are associated with the risk of dementia and AD. Methods The glycemic load (GL) was quantified in 2777 elderly participants from the French Three‐City Study to estimate RF intake. Then, the associations between GL and risk of dementia and AD, and the interaction with APOE‐ε4 over a 12‐year period were assessed using proportional hazards models. Results After adjustment for potential confounders, high afternoon‐snack GL was associated with increased dementia and AD risk in APOE‐ε4 carriers (hazard ratio = 1.27 [1.03–1.56]). Discussion This study highlights that RF‐rich diets are a risk factor for dementia and AD in APOE‐ε4 carriers.
dc.language.isoENen_US
dc.subjectLEHA
dc.title.enRefined carbohydrate-rich diet is associated with long-term risk of dementia and Alzheimer's disease in apolipoprotein E epsilon4 allele carriers
dc.title.alternativeAlzheimers Dementen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.12114en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32506713en_US
bordeaux.journalAlzheimer's and Dementiaen_US
bordeaux.page1043-1053en_US
bordeaux.volume16en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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