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Cannabis use, depression and suicidal ideation in adolescence: direction of associations in a population based cohort

dc.rights.licenseopenen_US
dc.contributor.authorBOLANIS, Despina
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorORRI, Massimiliano
dc.contributor.authorCASTELLANOS-RYAN, Natalie
dc.contributor.authorRENAUD, Johanne
dc.contributor.authorMONTREUIL, Tina
dc.contributor.authorBOIVIN, Michel
dc.contributor.authorVITARO, Frank
dc.contributor.authorTREMBLAY, Richard
dc.contributor.authorTURECKI, Gustavo
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOTE, Sylvana
ORCID: 0000-0001-7944-0647
dc.contributor.authorSEGUIN, Jean R.
dc.contributor.authorGEOFFROY, Marie Claude
dc.date.accessioned2021-01-18T10:06:32Z
dc.date.available2021-01-18T10:06:32Z
dc.date.issued2020
dc.identifier.issn1573-2517 (Electronic) 0165-0327 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/25807
dc.description.abstractEnBackground To clarify the direction of the association between frequency of cannabis use, depressive symptoms and suicidal ideation from 15 to 20 years using cross-lagged analyses. Method We included 1606 adolescents from the province of Québec followed since 1997 with information on frequency of cannabis use (none/monthly/weekly), depression (defined as being in the top 10% symptoms) and serious suicidal ideation at ages 15, 17 and 20 years. Results The prevalence of weekly cannabis use increased from 7.0% at age 15 years to 15.6% by age 20 years. Adolescents who reported using cannabis weekly at one age were 11 to 15 times more likely to continue using cannabis over time. In longitudinal cross-lagged analyses, weekly cannabis use at age 15 was associated with greater odds (OR=2.19, 95% CI=1.04-4.58) of suicidal ideation two years later. However, other substance use (alcohol, tobacco, other drugs) fully explained this association. Further, depression predicted subsequent weekly cannabis use, even after adjusting for comorbid other substance use (eg, for depression at 15 years predicting cannabis use at 17 years: OR=2.30, 95% CI=1.19-4.43). Limitations Quantity of cannabis consumed was not measured. Conclusion Findings suggest that depressive symptoms in adolescence may represent a risk factor for weekly cannabis consumption, which once initiated is likely to remain chronic. Weekly cannabis use increased risk for suicidal ideation, but not independently from other substance use including alcohol, tobacco and other drugs.
dc.language.isoENen_US
dc.subjectHEALTHY
dc.title.enCannabis use, depression and suicidal ideation in adolescence: direction of associations in a population based cohort
dc.title.alternativeJ Affect Disorden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jad.2020.05.136en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32663935en_US
bordeaux.journalJournal of Affective Disordersen_US
bordeaux.page1076-1083en_US
bordeaux.volume274en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03166200
hal.version1
hal.date.transferred2021-03-11T09:36:30Z
hal.exporttrue
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