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Hepatitis C virus or hepatitis B virus coinfection and lymphoma risk in people living with HIV

dc.rights.licenseopenen_US
dc.contributor.authorBESSON, C.
dc.contributor.authorNOEL, N.
dc.contributor.authorLANCAR, R.
dc.contributor.authorPREVOT, S.
dc.contributor.authorALGARTE-GENIN, M.
dc.contributor.authorROSENTHAL, E.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorMEYOHAS, M. C.
dc.contributor.authorPARTISANI, M.
dc.contributor.authorOBERIC, L.
dc.contributor.authorGABARRE, J.
dc.contributor.authorGOUJARD, C.
dc.contributor.authorCHERET, A.
dc.contributor.authorARVIEUX, C.
dc.contributor.authorKATLAMA, C.
dc.contributor.authorSALMON, D.
dc.contributor.authorBOUE, F.
dc.contributor.authorCOSTELLO, R.
dc.contributor.authorHENDEL-CHAVEZ, H.
dc.contributor.authorTAOUFIK, Y.
dc.contributor.authorFONTAINE, H.
dc.contributor.authorCOPPO, P.
dc.contributor.authorMOUNIER, N.
dc.contributor.authorDELOBEL, P.
dc.contributor.authorCOSTAGLIOLA, D.
dc.date.accessioned2021-01-14T10:20:49Z
dc.date.available2021-01-14T10:20:49Z
dc.date.issued2020
dc.identifier.issn1473-5571 (Electronic) 0269-9370 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/25774
dc.description.abstractEnObjective: Chronic hepatitis C virus (HCV) and hepatitis B virus (HBV) infections are associated with increased risks of lymphomas in the non-HIV setting. Their impacts on HIV-associated lymphomas deserved further studies in the modern combined antiretroviral therapy (cART) era. Design: We evaluated the associations between HCV, HBV and HIV-related lymphomas in the Lymphovir-ANRS-CO16 cohort. Methods: Prevalence of HCV seropositivity and chronic HBV infections were compared with those observed in the French Hospital Database on HIV (FHDH-ANRS-CO4). Results: Between 2008 and 2015, 179 patients with HIV-related lymphomas from 32 French hospitals were enrolled, 69 had Hodgkin's lymphoma (39%), and 110 non-Hodgkin's lymphoma (NHL) (61%). The prevalence of HCV infection was higher in patients with NHL than in the FHDH-ANRS-CO4 [26 versus 14%, odd ratio (OR): 2.15; 95% confidence interval (1.35–3.32)] whereas there was no association between Hodgkin's lymphoma and chronic HCV infection. Chronic HBV infection was not associated with NHL in our cohort with a prevalence of 5 versus 7% in FHDH-ANRS-CO4 but tended to be associated with Hodgkin's lymphoma [prevalence of 14%, OR: 2.16 (0.98–4.27)]. Chronic HCV infection tended to pejoratively impact 2-year overall survival in patients with NHL: 72% [57%, 91%] versus 82% [74%, 91%], hazard ratio: 2.14 [0.95–4.84]. In contrast, chronic HBV infection did not correlate with outcome. Conclusion: In the modern cART era, chronic HCV infection is associated with an increased risk of NHL in PLWHIV and tends to pejoratively impact overall survival. HBV infection is not associated with the risk of NHL but with a borderline increase of Hodgkin's lymphoma risk.
dc.language.isoENen_US
dc.subjectIDLIC
dc.title.enHepatitis C virus or hepatitis B virus coinfection and lymphoma risk in people living with HIV
dc.title.alternativeAIDSen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qad.0000000000002461en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31833850en_US
bordeaux.journalAIDSen_US
bordeaux.page599-608en_US
bordeaux.volume34en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamIDLICen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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