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Does amnesia specifically predict Alzheimer's pathology? A neuropathological study

dc.rights.licenseopenen_US
dc.contributor.authorBERTOUX, M.
dc.contributor.authorCASSAGNAUD, P.
dc.contributor.authorLEBOUVIER, T.
dc.contributor.authorLEBERT, F.
dc.contributor.authorSARAZIN, M.
dc.contributor.authorLE BER, I.
dc.contributor.authorDUBOIS, B.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAURIACOMBE, Sophie
dc.contributor.authorHANNEQUIN, D.
dc.contributor.authorWALLON, D.
dc.contributor.authorCECCALDI, M.
dc.contributor.authorMAURAGE, C. A.
dc.contributor.authorDERAMECOURT, V.
dc.contributor.authorPASQUIER, F.
dc.date.accessioned2021-01-14T09:12:47Z
dc.date.available2021-01-14T09:12:47Z
dc.date.issued2020
dc.identifier.issn1558-1497 (Electronic) 0197-4580 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/25773
dc.description.abstractEnAmnesia is a key component of Alzheimer’s disease (AD) and the most important feature of its clinical diagnosis but its specificity has recently been challenged. This study investigated the ability of amnesia to predict AD in a clinicopathological dementia series. Ninety-one patients to which free and cued verbal memory assessment was administered during early cognitive decline, were followed until autopsy. Patients’ histological diagnoses were classified as pure AD, mixed AD, and non-AD pathologies. Data-driven automated classification procedures explored the correspondence between memory performance and pathological diagnoses. Classifications revealed 3 clusters of performance reflecting different levels of amnesia. Little correspondence between these clusters and the presence of AD pathology was retrieved. A third of patients with pure/mixed AD pathology were non-amnesic at presentation and ≈45% of patients without AD pathology were amnesic. Data-driven prediction of AD pathology based on memory also had a poor accuracy. Free and cued memory assessments are fair tools to diagnose an amnesic syndrome but lack accuracy to predict AD pathology.
dc.language.isoENen_US
dc.subjectSEPIA
dc.title.enDoes amnesia specifically predict Alzheimer's pathology? A neuropathological study
dc.title.alternativeNeurobiol Agingen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neurobiolaging.2020.07.011en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32795849en_US
bordeaux.journalNeurobiology of Agingen_US
bordeaux.page123-130en_US
bordeaux.volume95en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03166387
hal.version1
hal.date.transferred2021-03-11T10:31:22Z
hal.exporttrue
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