The type 2 diabetes-specific dementia risk score (DSDRS) is associated with frailty, cognitive and functional status amongst Mexican community-dwelling older adults
| dc.rights.license | open | en_US |
| dc.contributor.author | BELLO-CHAVOLLA, O. Y. | |
| dc.contributor.author | AGUILAR-SALINAS, C. A. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | AVILA-FUNES, Jose Alberto | |
| dc.date.accessioned | 2021-01-13T14:18:32Z | |
| dc.date.available | 2021-01-13T14:18:32Z | |
| dc.date.issued | 2020 | |
| dc.identifier.issn | 1471-2318 (Electronic) 1471-2318 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/25759 | |
| dc.description.abstractEn | Background The type 2 diabetes (T2D) specific dementia-risk score (DSDRS) was developed to evaluate dementia risk in older adults with T2D. T2D-related factors have been shown increase the risk of age-related conditions, which might also increase dementia risk. Here, we investigate the associations of DSDRS with frailty, disability, quality of life (QoL) and cognition in community-dwelling older adults with T2D. Methods We included 257 community-dwelling older adults with T2D to evaluate the association between DSDRS and Mini-mental state examination (MMSE), Isaac’s set-test (IST), clock drawing test (CDT), quality of life (SF-36), risk of malnutrition (Mini-Nutritional Assessment or MNA), as well as frailty, Katz’ and Lawton-Brody scores. We also assessed the phenotype and correlates of high-estimated dementia risk by assessing individuals with DSDRS >75th age-specific percentiles. Results Mean age of participants was 78.0 ± 6.2 years. DSDRS showed a significant correlation with MMSE test, IST, CDT, SF-36, MNA, Lawton-Brody and Katz scores, and an increasing number of frailty components. DSDRS was higher among frail, pre-frail, and subjects with limited ADL and IADL (p < 0.001). Participants with DSDRS >75th age-specific percentiles had lower education, MMSE, IST, SF-36, MNA, Katz, Lawton-Brody, and higher frailty scores. High-estimated 10-year dementia risk was associated with ADL and IADL disability, frailty and risk of malnutrition. When assessing individual components of DSDRS, T2D-related microvascular complications were associated to all outcome measures. Conclusion The DSDRS is associated with frailty, disability, malnutrition and lower cognitive performance. These findings support that T2D-related factors have significant burden on functional status, QoL, disability and dementia risk. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject | SEPIA | |
| dc.title.en | The type 2 diabetes-specific dementia risk score (DSDRS) is associated with frailty, cognitive and functional status amongst Mexican community-dwelling older adults | |
| dc.title.alternative | BMC Geriatr | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1186/s12877-020-01776-5 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 32962659 | en_US |
| bordeaux.journal | BMC Geriatrics | en_US |
| bordeaux.page | 363 | en_US |
| bordeaux.volume | 20 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | SEPIA | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03167402 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-12T08:27:08Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMC%20Geriatrics&rft.date=2020&rft.volume=20&rft.issue=1&rft.spage=363&rft.epage=363&rft.eissn=1471-2318%20(Electronic)%201471-2318%20(Linking)&rft.issn=1471-2318%20(Electronic)%201471-2318%20(Linking)&rft.au=BELLO-CHAVOLLA,%20O.%20Y.&AGUILAR-SALINAS,%20C.%20A.&AVILA-FUNES,%20Jose%20Alberto&rft.genre=article |
