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Chikungunya Arthritis: Implications of Acute and Chronic Inflammation Mechanisms on Disease Management

dc.rights.licenseopenen_US
dc.contributor.authorZAID, A.
dc.contributor.authorGERARDIN, P.
dc.contributor.authorTAYLOR, A.
dc.contributor.authorMOSTAFAVI, H.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMALVY, Denis
ORCID: 0000-0003-1948-9355
IDREF: 148480993
dc.contributor.authorMAHALINGAM, S.
dc.date.accessioned2021-01-07T11:05:02Z
dc.date.available2021-01-07T11:05:02Z
dc.date.issued2018-04
dc.identifier.issn2326-5205 (Electronic) 2326-5191 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/23734
dc.description.abstractEnIn the past decade, arboviruses - arthropod-borne viruses - have been the focus of public health institutions worldwide following a spate of devastating outbreaks. Chikungunya virus (CHIKV), an arbovirus that belongs to the alphavirus genus, is a re-emerging arthritogenic virus that has caused explosive outbreaks since 2006, notably in the Reunion Island, and more recently in the Caribbean, South America, India and South-East Asia. The severity of arthritic disease caused by CHIKV has prompted public health authorities of affected countries to develop specific guidelines to tackle this pathogen. CHIKV disease (CHIKVD) manifests first as an acute stage of severe joint inflammation and febrile illness, which later progresses to a chronic stage, where patients can experience debilitating and persisting articular pain for extended periods. This review aims to provide a broad perspective on current knowledge of CHIKV pathogenesis by identifying key clinical and experimental studies that have contributed to our understanding of CHIKVD to date. In addition, this review explores the practical aspects treatment and management of both acute and chronic CHIKVD patients based on clinical experience during CHIKV outbreaks. Finally, recent findings on potential therapeutic solutions - from antivirals to immunomodulatory drugs - are reviewed to provide both viral immunologists and clinical rheumatologists with a balanced perspective on the nature of a re-emerging arboviral disease of significant public health concern, and an insight into future therapeutic approaches to better address the treatment and management of CHIKVD patients.
dc.language.isoENen_US
dc.subject.enIDLIC
dc.title.enChikungunya Arthritis: Implications of Acute and Chronic Inflammation Mechanisms on Disease Management
dc.title.alternativeArthritis Rheumatolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/art.40403en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29287308en_US
bordeaux.journalArthritis & rheumatologyen_US
bordeaux.page484-495en_US
bordeaux.volume70en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamIDLICen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03194142
hal.version1
hal.date.transferred2021-04-09T11:05:21Z
hal.exporttrue
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