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Impact of Alcohol and Coffee Intake on the Risk of Advanced Liver Fibrosis: A Longitudinal Analysis in HIV-HCV Coinfected Patients (ANRS HEPAVIH CO-13 Cohort)

dc.rights.licenseopenen_US
dc.contributor.authorYAYA, I.
dc.contributor.authorMARCELLIN, F.
dc.contributor.authorCOSTA, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMORLAT, Philippe
dc.contributor.authorPROTOPOPESCU, C.
dc.contributor.authorPIALOUX, G.
dc.contributor.authorSANTOS, M. E.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorESTERLE, Laure
dc.contributor.authorGERVAIS, A.
dc.contributor.authorSOGNI, P.
dc.contributor.authorSALMON-CERON, D.
dc.contributor.authorCARRIERI, M. P.
dc.date.accessioned2021-01-07T10:31:43Z
dc.date.available2021-01-07T10:31:43Z
dc.date.issued2018-05-31
dc.identifier.issn2072-6643 (Electronic) 2072-6643 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/23731
dc.description.abstractEnBACKGROUND: Coffee intake has been shown to modulate both the effect of ethanol on serum GGT activities in some alcohol consumers and the risk of alcoholic cirrhosis in some patients with chronic diseases. This study aimed to analyze the impact of coffee intake and alcohol consumption on advanced liver fibrosis (ALF) in HIV-HCV co-infected patients. METHODS: ANRS CO13-HEPAVIH is a French, nationwide, multicenter cohort of HIV-HCV-co-infected patients. Sociodemographic, behavioral, and clinical data including alcohol and coffee consumption were prospectively collected using annual self-administered questionnaires during five years of follow-up. Mixed logistic regression models were performed, relating coffee intake and alcohol consumption to ALF. RESULTS: 1019 patients were included. At the last available visit, 5.8% reported high-risk alcohol consumption, 27.4% reported high coffee intake and 14.5% had ALF. Compared with patients with low coffee intake and high-risk alcohol consumption, patients with low coffee intake and low-risk alcohol consumption had a lower risk of ALF (aOR (95% CI) 0.24 (0.12(-)0.50)). In addition, patients with high coffee intake had a lower risk of ALF than the reference group (0.14 (0.03(-)0.64) in high-risk alcohol drinkers and 0.11 (0.05(-)0.25) in low-risk alcohol drinkers). CONCLUSIONS: High coffee intake was associated with a low risk of liver fibrosis even in HIV-HCV co-infected patients with high-risk alcohol consumption.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enMORPH3Eus
dc.subject.enCIC1401
dc.subject.enANRS CO13 HEPAVIH
dc.title.enImpact of Alcohol and Coffee Intake on the Risk of Advanced Liver Fibrosis: A Longitudinal Analysis in HIV-HCV Coinfected Patients (ANRS HEPAVIH CO-13 Cohort)
dc.title.alternativeNutrientsen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/nu10060705en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29857547en_US
bordeaux.journalNutrientsen_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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