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Multivalent Elastin-Like Glycopolypeptides: Subtle Chemical Structure Modifications with High Impact on Lectin Binding Affinity
dc.rights.license | embargo | en_US |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | ROSSELIN, Marie | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | CHINOY, Zoeisha S. | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | BRAVO-ANAYA, Lourdes Mónica | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | GARANGER, Elisabeth
IDREF: 089451740 | |
dc.date.accessioned | 2021-01-06T16:54:40Z | |
dc.date.available | 2021-01-06T16:54:40Z | |
dc.date.issued | 2020-12-17 | |
dc.identifier.issn | 2161-1653 | en_US |
dc.identifier.uri | oai:crossref.org:10.1021/acsmacrolett.0c00775 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/23718 | |
dc.description.abstractEn | A library of synthetic elastin-like glycopolypeptides were synthesized and screened by microscale thermophoresis to identify key structural parameters affecting lectin binding efficacy. While polypeptide backbone size and glycovalency were found to have little influence, the presence of a linker at the anomeric position of galactose and the absence of positive charge on the polypeptide residue holding the sugar unit were found to be critical for the binding to RCA120. | |
dc.description.sponsorship | Développement de squelettes polypeptidiques recombinants pour la synthèse de glycoconjugués multivalents parfaitement définis - ANR-15-CE07-0002 | en_US |
dc.language.iso | EN | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.source | crossref | |
dc.subject.en | Elastin-like polypeptides (ELPs) | |
dc.subject.en | saccharides | |
dc.subject.en | glycoconjugates | |
dc.subject.en | chemoselective modifications | |
dc.subject.en | macromolecular click chemistry | |
dc.subject.en | lectins | |
dc.title.en | Multivalent Elastin-Like Glycopolypeptides: Subtle Chemical Structure Modifications with High Impact on Lectin Binding Affinity | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1021/acsmacrolett.0c00775 | en_US |
dc.subject.hal | Chimie/Polymères | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Biotechnologies | en_US |
bordeaux.journal | ACS Macro Letters | en_US |
bordeaux.page | 65-70 | en_US |
bordeaux.volume | 10 | en_US |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | en_US |
bordeaux.institution | Bordeaux INP | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
bordeaux.import.source | dissemin | |
hal.identifier | hal-03100778 | |
hal.version | 1 | |
hal.date.transferred | 2021-01-06T16:54:45Z | |
hal.export | true | |
workflow.import.source | dissemin | |
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