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Abacavir use and risk of recurrent myocardial infarction

dc.rights.licenseopenen_US
dc.contributor.authorSABIN, C. A.
dc.contributor.authorRYOM, L.
dc.contributor.authorD'ARMINIO MONFORTE, A.
dc.contributor.authorHATLEBERG, C. I.
dc.contributor.authorPRADIER, C.
dc.contributor.authorEL-SADR, W.
dc.contributor.authorKIRK, O.
dc.contributor.authorWEBER, R.
dc.contributor.authorPHILLIPS, A. N.
dc.contributor.authorMOCROFT, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorLAW, M.
dc.contributor.authorDE WIT, S.
dc.contributor.authorREISS, P.
dc.contributor.authorLUNDGREN, J. D.
dc.date.accessioned2021-01-04T11:28:02Z
dc.date.available2021-01-04T11:28:02Z
dc.date.issued2018-01-02
dc.identifier.issn1473-5571 (Electronic) 0269-9370 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/23617
dc.description.abstractEnOBJECTIVE: To investigate the association between abacavir (ABC) use and recurrent myocardial infarction (MI) among HIV-positive people with a prior MI. DESIGN: International multicohort collaboration with follow-up from 1999 to 2016. METHODS: The rate of recurrent MI was described among D:A:D participants who experienced an index MI whilst in the study, and who remained under follow-up beyond 28 days after this MI. Follow-up was considered to the date of next MI, death, 1 February 2016 or 6 months after last clinic visit. Poisson regression models considered associations between recurrent MI and exposure to ABC (use at index MI, current post-MI exposure and cumulative exposure), before and after adjusting for calendar year. RESULTS: The 984 individuals who experienced an index MI during the study (91.3% male, median age 51 at index MI) were followed for 5312 person-years, over which time there were 136 recurrent MIs (rate 2.56/100 person-years, 95% confidence interval 2.13-2.99). Rates were 2.40 (1.71-3.09) and 2.65 (2.10-3.21)/100 person-years in those who were and were not on ABC, respectively, at the index MI, and 2.90 (2.01-3.78) and 2.44 (1.95-2.93)/100 person-years in those who were and were not currently receiving ABC, respectively, post-MI. No association was seen with recurrent MI and either cumulative exposure to ABC [relative rate 0.86 (0.68-1.10)/5 years], receipt of ABC at index MI [0.90 (0.63-1.29)] nor recent post-MI exposure to ABC [1.19 (0.82-1.71)]. CONCLUSION: Among people with a previous MI, there was no evidence for an association between use of ABC post-MI and an elevated risk of a recurrent MI.
dc.language.isoENen_US
dc.subject.enMORPH3Eus
dc.subject.enDAD
dc.title.enAbacavir use and risk of recurrent myocardial infarction
dc.title.alternativeAIDSen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qad.0000000000001666en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29028664en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.page79-88en_US
bordeaux.volume32en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.teamDADen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03193806
hal.version1
hal.date.transferred2021-04-09T07:46:38Z
hal.exporttrue
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