Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk
| dc.rights.license | open | en_US |
| dc.contributor.author | OLSON, N. C. | |
| dc.contributor.author | RAFFIELD, L. M. | |
| dc.contributor.author | LANGE, L. A. | |
| dc.contributor.author | LANGE, E. M. | |
| dc.contributor.author | LONGSTRETH, W. T., Jr. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | CHAUHAN, Ganesh | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DEBETTE, Stephanie | |
| dc.contributor.author | SESHADRI, Sudha | |
| dc.contributor.author | REINER, A. P. | |
| dc.contributor.author | TRACY, R. P. | |
| dc.date.accessioned | 2020-12-14T08:45:46Z | |
| dc.date.available | 2020-12-14T08:45:46Z | |
| dc.date.issued | 2018-01 | |
| dc.identifier.issn | 1538-7836 (Electronic) 1538-7836 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/21421 | |
| dc.description.abstractEn | BACKGROUND: A fraction of coagulation factor VII circulates as an active protease (FVIIa). FVIIa also circulates as an inactivated complex with antithrombin (FVIIa-AT). OBJECTIVE: Evaluate associations of FVIIa and FVIIa-AT with genome-wide single nucleotide polymorphisms (SNPs) and incident coronary heart disease, ischemic stroke, and mortality. PATIENTS/METHODS: We measured FVIIa and FVIIa-AT in 3,486 Cardiovascular Health Study (CHS) participants. We performed a genome-wide association scan for FVIIa and FVIIa-AT in European-Americans (n=2,410) and examined associations of FVII phenotypes with incident cardiovascular disease. RESULTS: In European-Americans, the most significant SNP for FVIIa and FVIIa-AT was rs1755685 in the F7 promoter region on chromosome 13 (FVIIa: beta= -25.9 mU/mL per minor allele; FVIIa-AT: beta= -26.6 pM per minor allele). Phenotypes were also associated with rs867186 located in PROCR on chromosome 20 (FVIIa: beta= 7.8 mU/mL per minor allele; FVIIa-AT: beta= 9.9 per minor allele). Adjusted for risk factors, a 1-standard deviation higher FVIIa was associated with increased ischemic stroke risk (hazard ratio (HR) = 1.12; 95% confidence interval (CI): 1.01, 1.23). Higher FVIIa-AT was associated with mortality from all-causes (HR: 1.08, 95% CI: 1.03, 1.12). Among European-American CHS participants the rs1755685 minor allele was associated with lower ischemic stroke (HR=0.69, 95% CI: 0.54, 0.88), but this association was not replicated in a larger multi-cohort analysis. CONCLUSIONS: Results support the importance of the F7 and PROCR loci on variation in circulating FVIIa and FVIIa-AT. Findings suggest FVIIa is a risk factor for ischemic stroke in older adults while higher FVIIa-AT may reflect mortality risk. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | VINTAGE | |
| dc.title.en | Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk | |
| dc.title.alternative | J Thromb Haemost | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/jth.13899 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 29112333 | en_US |
| bordeaux.journal | Journal of Thrombosis and Haemostasis | en_US |
| bordeaux.page | 19-30 | en_US |
| bordeaux.volume | 16 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | VINTAGE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03194200 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-09T11:40:56Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Thrombosis%20and%20Haemostasis&rft.date=2018-01&rft.volume=16&rft.issue=1&rft.spage=19-30&rft.epage=19-30&rft.eissn=1538-7836%20(Electronic)%201538-7836%20(Linking)&rft.issn=1538-7836%20(Electronic)%201538-7836%20(Linking)&rft.au=OLSON,%20N.%20C.&RAFFIELD,%20L.%20M.&LANGE,%20L.%20A.&LANGE,%20E.%20M.&LONGSTRETH,%20W.%20T.,%20Jr.&rft.genre=article |
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