Double-hit or dual expression of MYC and BCL2 in primary cutaneous large B-cell lymphomas
| dc.rights.license | open | en_US |
| dc.contributor.author | MENGUY, S. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FRISON, Éric | |
| dc.contributor.author | PROCHAZKOVA-CARLOTTI, M. | |
| dc.contributor.author | DALLE, S. | |
| dc.contributor.author | DEREURE, O. | |
| dc.contributor.author | BOULINGUEZ, S. | |
| dc.contributor.author | DALAC, S. | |
| dc.contributor.author | MACHET, L. | |
| dc.contributor.author | RAM-WOLFF, C. | |
| dc.contributor.author | VERNEUIL, L. | |
| dc.contributor.author | GROS, A. | |
| dc.contributor.author | VERGIER, B. | |
| dc.contributor.author | BEYLOT-BARRY, M. | |
| dc.contributor.author | MERLIO, J. P. | |
| dc.contributor.author | PHAM-LEDARD, A. | |
| dc.date.accessioned | 2020-12-07T14:49:03Z | |
| dc.date.available | 2020-12-07T14:49:03Z | |
| dc.date.issued | 2018-08 | |
| dc.identifier.issn | 1530-0285 (Electronic) 0893-3952 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/21331 | |
| dc.description.abstractEn | In nodal diffuse large B-cell lymphoma, the search for double-hit with MYC and BCL2 and/or BCL6 rearrangements or for dual expression of BCL2 and MYC defines subgroups of patients with altered prognosis that has not been evaluated in primary cutaneous large B-cell lymphoma. Our objectives were to assess the double-hit and dual expressor status in a cohort of 44 patients with primary cutaneous large B-cell lymphoma according to the histological subtype and to evaluate their prognosis relevance. The 44 cases defined by the presence of more than 80% of large B-cells in the dermis corresponded to 21 primary cutaneous follicle centre lymphoma with large cell morphology and 23 primary cutaneous diffuse large B-cell lymphoma, leg type. Thirty-one cases (70%) expressed BCL2 and 29 (66%) expressed MYC. Dual expressor profile was observed in 25 cases (57%) of either subtypes (n = 6 or n = 19, respectively). Only one primary cutaneous follicle centre lymphoma, large-cell case had a double-hit status (2%). Specific survival was significantly worse in primary cutaneous diffuse large B-cell lymphoma, leg type than in primary cutaneous follicle centre lymphoma, large cell (p = 0.021) and for the dual expressor primary cutaneous large B-cell lymphoma group (p = 0.030). Both overall survival and specific survival were worse for patients belonging to the dual expressor primary cutaneous diffuse large B-cell lymphoma, leg type subgroup (p = 0.001 and p = 0.046, respectively). Expression of either MYC and/or BCL2 negatively impacted overall survival (p = 0.017 and p = 0.018 respectively). As the differential diagnosis between primary cutaneous follicle centre lymphoma, large cell and primary cutaneous diffuse large B-cell lymphoma, leg type has a major impact on prognosis, dual-expression of BCL2 and MYC may represent a new diagnostic criterion for primary cutaneous diffuse large B-cell lymphoma, leg type subtype and further identifies patients with impaired survival. Finally, the double-hit assessment does not appear clinically relevant in primary cutaneous large B-cell lymphoma. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | USMR | |
| dc.title.en | Double-hit or dual expression of MYC and BCL2 in primary cutaneous large B-cell lymphomas | |
| dc.title.alternative | Mod Pathol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41379-018-0041-7 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 29581544 | en_US |
| bordeaux.journal | Modern pathology | en_US |
| bordeaux.page | 1332-1342 | en_US |
| bordeaux.volume | 31 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 8 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | USMR | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Modern%20pathology&rft.date=2018-08&rft.volume=31&rft.issue=8&rft.spage=1332-1342&rft.epage=1332-1342&rft.eissn=1530-0285%20(Electronic)%200893-3952%20(Linking)&rft.issn=1530-0285%20(Electronic)%200893-3952%20(Linking)&rft.au=MENGUY,%20S.&FRISON,%20%C3%89ric&PROCHAZKOVA-CARLOTTI,%20M.&DALLE,%20S.&DEREURE,%20O.&rft.genre=article |
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