Pattern of polyphenol intake and the long-term risk of dementia in older persons
dc.rights.license | open | en_US |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | LEFEVRE ARBOGAST, Sophie | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | GAUDOUT, David | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | BENSALEM, Julien | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | LETENNEUR, Luc | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529 IDREF: 058586105 | |
hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | HEJBLUM, Boris
ORCID: 0000-0003-0646-452X IDREF: 189970316 | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | FEART-COURET, Catherine
ORCID: 0000-0002-7959-1610 IDREF: 08195848X | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DELCOURT, Cecile
ORCID: 0000-0002-2099-0481 IDREF: 035105291 | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | SAMIERI, Cecilia | |
dc.date.accessioned | 2020-11-30T10:17:11Z | |
dc.date.available | 2020-11-30T10:17:11Z | |
dc.date.issued | 2018-05-29 | |
dc.identifier.issn | 1526-632X (Electronic) 0028-3878 (Linking) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/21254 | |
dc.description.abstractEn | OBJECTIVE: To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study. METHODS: We included 1,329 older adults without dementia from the 3C study with assessment of intake of 26 polyphenol subclasses who were followed up for 12 years for dementia. Using partial least squares for Cox models, we identified a pattern of polyphenol intake associated with dementia risk. RESULTS: The pattern combined several flavonoids (dihydroflavonols, anthocyanins, isoflavonoids, flavanones), stilbenes (including resveratrol), lignans, and other subclasses (hydroxybenzaldehydes, naphthoquinones, furanocoumarins). Compared with participants in the lower quintile of pattern score, those in the higher quintile had a 50% lower risk of dementia (95% confidence interval 20%-68%, p for trend <0.01) in multivariate models. CONCLUSIONS: In this French cohort, a polyphenol pattern provided by a diet containing specific plant products (nuts, citrus, berries, leafy vegetables, soy, cereals, olive oil) accompanied by red wine and tea was associated with lower dementia risk. | |
dc.language.iso | EN | en_US |
dc.subject.en | LEHA | |
dc.subject.en | SISTM | |
dc.subject.en | SEPIA | |
dc.title.en | Pattern of polyphenol intake and the long-term risk of dementia in older persons | |
dc.title.alternative | Neurology | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1212/wnl.0000000000005607 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 29703769 | en_US |
bordeaux.journal | Neurology | en_US |
bordeaux.page | e1979-e1988 | en_US |
bordeaux.volume | 90 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
bordeaux.issue | 22 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.team | SISTM_BPH | en_US |
bordeaux.team | LEHA_BPH | |
bordeaux.team | SEPIA | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.export | false | |
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