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Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study

dc.rights.licenseopenen_US
dc.contributor.authorLATOURTE, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSOUMARE, Aicha
dc.contributor.authorBARDIN, T.
dc.contributor.authorPEREZ-RUIZ, F.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorRICHETTE, P.
dc.date.accessioned2020-11-30T09:32:30Z
dc.date.available2020-11-30T09:32:30Z
dc.date.issued2018-03
dc.identifier.issn1468-2060 (Electronic) 0003-4967 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21250
dc.description.abstractEnOBJECTIVES: In patients with gout, maintaining too low serum uric acid (SUA) level with urate-lowering therapy is a concern because uric acid is thought to be neuroprotective. However, the relation between SUA and dementia remains debated. This study aimed to investigate the impact of SUA level on the incidence of dementia. METHODS: We assessed the longitudinal association between SUA level and incident dementia (Diagnostic and Statistical Manual of Mental Disorders Version IV (DSM-IV) criteria) in a large cohort of healthy older people from the community (Three-City Dijon cohort). Additionally, we investigated the relation between SUA level and MRI markers of brain ageing (white matter hyperintensity volume (WMHV), lacunes and hippocampal volume). RESULTS: The study sample comprised 1598 people (mean (SD) age 72.4(4.1) years, 38.3% male). During the 13,357 person-years of follow-up (median duration: 10.1 years), dementia developed in 110 participants (crude incidence rate: 8.2/1000 person-years). After multiple adjustments, the multivariate HR with the highest (>/=75th percentile) versus lowest SUA level was 1.79 (95% CI 1.17 to 2.73; p=0.007). The association was stronger with vascular or mixed dementia (HR=3.66 (95% CI 1.29 to 10.41), p=0.015) than Alzheimer's disease (HR=1.55 (95% CI 0.92 to 2.61), p=0.10). There was a non-significant trend towards an association between high SUA level and extensive WMHV (p=0.10), a biomarker of small vessel disease, but not hippocampal volume (p=0.94) or lacunes (p=0.86). The association between SUA level and vascular or mixed dementia might be affected by interim strokes. CONCLUSIONS: Risk of dementia, especially vascular or mixed dementia, may be increased with high SUA levels in elderly people.
dc.language.isoENen_US
dc.subject.enVINTAGE
dc.title.enUric acid and incident dementia over 12 years of follow-up: a population-based cohort study
dc.title.alternativeAnn Rheum Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/annrheumdis-2016-210767en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed28754803en_US
bordeaux.journalAnnals of the Rheumatic Diseasesen_US
bordeaux.page328-335en_US
bordeaux.volume77en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03194175
hal.version1
hal.date.transferred2021-04-09T11:29:57Z
hal.exporttrue
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