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Serum 25-Hydroxyvitamin D Concentrations and Ischemic Stroke and Its Subtypes

dc.rights.licenseopenen_US
dc.contributor.authorLARSSON, S. C.
dc.contributor.authorTRAYLOR, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMISHRA, Aniket
dc.contributor.authorHOWSON, J. M. M.
dc.contributor.authorMICHAELSSON, K.
dc.contributor.authorMARKUS, H. S.
dc.date.accessioned2020-11-30T08:53:20Z
dc.date.available2020-11-30T08:53:20Z
dc.date.issued2018-10
dc.identifier.issn0039-2499en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21248
dc.description.abstractEnBackground and Purpose- Observational studies have reported increased risk of ischemic stroke among individuals with low serum 25-hydroxyvitamin D (S-25OHD) concentrations but uncertainty remains about the causality of this association. We sought to determine whether S-25OHD concentrations are causally associated with ischemic stroke and its subtypes using Mendelian randomization. Methods- We used summary-level data for ischemic stroke (34 217 cases and 404 630 noncases) from the MEGASTROKE consortium. As instruments, we used 6 single nucleotide polymorphisms, explaining 7.5% of the variance in S-25OHD, previously identified to be associated with S-25OHD concentrations in the Study of Underlying Genetic Determinants of Vitamin D and Highly Related Traits consortium (n=79 366). The analyses were conducted using the inverse-variance-weighted method and complemented with the weighted median, heterogeneity-penalized, and Mendelian randomization-Egger approaches. Results- Genetically higher S-25OHD concentration was not associated with ischemic stroke. The odds ratios (95% CI) per genetically predicted 1-SD ( approximately 18 nmol/L) increase in S-25OHD concentrations, based on all 6 single nucleotide polymorphisms, were 1.01 (0.94-1.08; P=0.84) for all ischemic stroke, 0.94 (0.80-1.11; P=0.49) for large artery stroke, 0.95 (0.82-1.11; P=0.55) for small vessel stroke, and 1.02 (0.90-1.16; P=0.74) for cardioembolic stroke. The results were similar in sensitivity analyses. Conclusions- These findings provide no support that higher S-25OHD concentrations are causally associated with any ischemic stroke subtype. Thus, vitamin D supplementation will unlikely reduce the risk of ischemic stroke in the general population.
dc.language.isoENen_US
dc.subject.enVINTAGE
dc.title.enSerum 25-Hydroxyvitamin D Concentrations and Ischemic Stroke and Its Subtypes
dc.title.alternativeStrokeen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1161/strokeaha.118.022242en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30355092en_US
bordeaux.journalStrokeen_US
bordeaux.page2508-2511en_US
bordeaux.volume49en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03030443
hal.version1
hal.date.transferred2020-11-30T08:53:27Z
hal.exporttrue
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