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Synthesis of block copolypeptides by click chemistry
| dc.rights.license | open | |
| hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
| dc.contributor.author | AGUT, Willy | |
| hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
| dc.contributor.author | AGNAOU, Reda | |
| hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | LECOMMANDOUX, Sebastien | |
| hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
| hal.structure.identifier | Team 1 LCPO : Polymerization Catalyses & Engineering | |
| dc.contributor.author | TATON, Daniel | |
| dc.date.accessioned | 2020 | |
| dc.date.available | 2020 | |
| dc.date.created | 2008 | |
| dc.date.issued | 2008 | |
| dc.identifier.issn | 1022-1336 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20792 | |
| dc.description.abstractEn | A novel synthetic methodology to diblock copolypeptides was developed by ring-opening polymerization (ROP) of N-carboxyanhydrides (NCAs) from alpha-omega-functionalized initiators combined with the Huisgen 1,3 dipolar cycloaddition (click chemistry). Poly(gamma-benzyl-L-glutamate) (PBLGlu) and poly(trifluoroacetyl-L-Lysine) (PTFALys) containing either an azide or an alkyne functional group in alpha-position were first synthesized by ROP of the corresponding NCA at room temperature in DMF as a solvent, using appropriate omega-amino-containing alpha-alkyne and a-azido difunctional initiators. The Copper(I) -catalyzed coupling reactions of alpha-azido-PBLGlu with the alpha-alkyne-PTFALys, on the one hand, and of the alpha-alkyne-PBLGlu with the alpha-azido-PTFALys, on the other hand were suitably accomplished in DMF. This afforded the targeted PBLGlu-b-PTFALys diblock copolypeptides pos- sessing a triazole group in between the two 1 blocks, as evidenced by SEC, IR, and NMR analysis. Block copolypeptides could be successfully purified by selective extraction with chloroform. | |
| dc.language.iso | en | |
| dc.publisher | Wiley-VCH Verlag | |
| dc.subject.en | L-LYSINE | |
| dc.subject.en | L-LEUCINE | |
| dc.subject.en | MODULAR SYNTHESIS | |
| dc.subject.en | ONE-POT SYNTHESIS | |
| dc.subject.en | L-GLUTAMIC ACID | |
| dc.subject.en | ROD-COIL | |
| dc.subject.en | TRIBLOCK COPOLYMERS | |
| dc.subject.en | DIBLOCK COPOLYMERS | |
| dc.subject.en | MATERIALS SCIENCE | |
| dc.subject.en | POLYPEPTIDE | |
| dc.title.en | Synthesis of block copolypeptides by click chemistry | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1002/marc.200800123 | |
| dc.subject.hal | Chimie/Polymères | |
| bordeaux.journal | Macromolecular Rapid Communications | |
| bordeaux.page | 1147-1155 | |
| bordeaux.volume | 29 | |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
| bordeaux.issue | 12-13 | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00338937 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00338937v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Macromolecular%20Rapid%20Communications&rft.date=2008&rft.volume=29&rft.issue=12-13&rft.spage=1147-1155&rft.epage=1147-1155&rft.eissn=1022-1336&rft.issn=1022-1336&rft.au=AGUT,%20Willy&AGNAOU,%20Reda&LECOMMANDOUX,%20Sebastien&TATON,%20Daniel&rft.genre=article |
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