cMFA for multi-omics data integration in microbial community models
| hal.structure.identifier | Biodiversité, Gènes & Communautés [BioGeCo] | |
| hal.structure.identifier | Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE] | |
| dc.contributor.author | TATHO DJEANOU, Sthyve Junior | |
| hal.structure.identifier | Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE] | |
| hal.structure.identifier | Biodiversité, Gènes & Communautés [BioGeCo] | |
| dc.contributor.author | LABARTHE, Simon | |
| hal.structure.identifier | Institut Sophia Agrobiotech [ISA] | |
| hal.structure.identifier | Modélisation et commande de systèmes biologiques et écologiques [MACBES] | |
| hal.structure.identifier | Université Côte d'Azur [UniCA] | |
| dc.contributor.author | BALDAZZI, Valentina | |
| dc.date.conference | 2025-10-05 | |
| dc.description.abstractEn | Understanding microbial community functions is challenging due to complex interactions and assembly mechanisms; however, advances in sequencing have enabled the collection of multi-omics data, including population counts and metabolomic or metatranscriptomic data. Our main objective is to develop a mathematical model capable of integrating time series of multiomics data at a community scale. We introduce the community metabolic flux analysis (cMFA) method, which generalizes metabolic flux analyses (MFA) , using a list of time series data of experimentally measured production and consumption rates of metabolites and microorganism growth . We aim to infer, for each member ofthe microbial community, the intracellular distribution of metabolic fluxes by solving the inference problem. We evaluated the cMFA method on synthetic data from dynamic models of increasingly complex microbial communities, based on metabolic models of different mutants of Escherichia coli using dynamic flux balance analysis . Synthetic metatranscriptomic data were obtained from internal metabolic fluxes in the dynamic model. Different regularization terms were tested, including different levels of sparsity, for the selected penalty weight . To evaluate the robustness of the method, multiplebenchmarks were tested. These included assessments of the robustness of the method to data noise, incomplete meta-transcriptomic data, inaccurate prior knowledge of metabolic import rates and larger microbial community. We are currently working with real data, including data on denitrification and cheese production | |
| dc.description.sponsorship | Computationel models of crop plant microbial biodiversity - ANR-22-PEAE-0011 | |
| dc.language.iso | en | |
| dc.rights.uri | http://creativecommons.org/licenses/by/ | |
| dc.subject.en | Inference | |
| dc.subject.en | Biological system | |
| dc.subject.en | Applied mathematics | |
| dc.subject.en | Dynamical system | |
| dc.title.en | cMFA for multi-omics data integration in microbial community models | |
| dc.type | Autre communication scientifique (congrès sans actes - poster - séminaire...) | |
| dc.subject.hal | Informatique [cs]/Bio-informatique [q-bio.QM] | |
| dc.subject.hal | Mathématiques [math] | |
| bordeaux.conference.title | CompSysBio 2025: Advanced lecture course on computational systems biology | |
| bordeaux.country | FR | |
| bordeaux.conference.city | Aussois | |
| bordeaux.peerReviewed | non | |
| hal.identifier | hal-05318560 | |
| hal.version | 1 | |
| hal.invited | non | |
| hal.proceedings | non | |
| hal.conference.organizer | Daniel Jost, CNRS / ENS Lyon | |
| hal.conference.end | 2025-10-10 | |
| hal.popular | oui | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-05318560v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=TATHO%20DJEANOU,%20Sthyve%20Junior&LABARTHE,%20Simon&BALDAZZI,%20Valentina&rft.genre=conference |
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