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Visualization of Trypanosoma brucei flagellar pocket collar biogenesis identifies two new cytoskeletal structures.

dc.rights.licenseopenen_US
dc.contributor.authorZELENÁ, Marie
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorCASAS, Elina
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorLAMBERT, Chloé
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorLANDREIN, Nicolas
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorDACHEUX, Denis
IDREF: 230332838
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorBERTIAUX, Eloïse
dc.contributor.authorABESAMIS, Kim Ivan
dc.contributor.authorDONG, Gang
dc.contributor.authorVARGA, Vladimir
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorROBINSON, Derrick Roy
IDREF: 11410350X
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorBONHIVERS, Mélanie
dc.date.accessioned2025-10-16T09:18:18Z
dc.date.available2025-10-16T09:18:18Z
dc.date.issued2025-10-09
dc.identifier.issn1545-7885en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207828
dc.description.abstractEnUnderstanding how cells assemble internal structures is central to cell biology. In Trypanosoma brucei, the flagellar pocket (FP) is essential for nutrient uptake, and immune evasion, and its formation depends on a cytoskeletal structure called the flagellar pocket collar (FPC). However, the mechanisms underlying FPC assembly remain poorly understood. In this study, we used cutting-edge ultrastructure expansion microscopy (U-ExM) to investigate FPC biogenesis in T. brucei. We mapped the formation of the proximal part of the new microtubule quartet (nMtQ) alongside flagellum growth, providing new insights into its assembly. Additionally, we tracked the localization dynamics of key structural proteins-BILBO1, MORN1, and BILBO2-during the biogenesis of the FPC and the hook complex (HC). Notably, we identified two previously undetected structures: the proFPC and the transient FPC-interconnecting fiber (FPC-IF), both of which appear to play crucial roles in linking and organizing cellular components during cell division. By uncovering these novel aspects of FPC biogenesis, our study significantly advances the understanding of cytoskeletal organization in trypanosomes and opens new avenues for exploring the functional significance of these structures.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enVisualization of Trypanosoma brucei flagellar pocket collar biogenesis identifies two new cytoskeletal structures.
dc.title.alternativePLoS Biolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1371/journal.pbio.3003429en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
dc.identifier.pubmed41066504en_US
bordeaux.journalPLoS Biologyen_US
bordeaux.pagee3003429en_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue10en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-05317439
hal.version1
hal.date.transferred2025-10-16T09:18:21Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS%20Biology&rft.date=2025-10-09&rft.volume=23&rft.issue=10&rft.spage=e3003429&rft.epage=e3003429&rft.eissn=1545-7885&rft.issn=1545-7885&rft.au=ZELEN%C3%81,%20Marie&CASAS,%20Elina&LAMBERT,%20Chlo%C3%A9&LANDREIN,%20Nicolas&DACHEUX,%20Denis&rft.genre=article


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