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Blood vessel and osteocyte networks concurrently rearrange during bone maturation and decline during aging in the femur of male mice

dc.rights.licenseopenen_US
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorPALMIER, Mathilde
dc.contributor.authorMAÎTRE, Marlène
dc.contributor.authorDOAT, Hélène
dc.contributor.authorLESTÉ-LASSERRE, Thierry
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBOIZIAU, Claudine
ORCID: 0000-0002-0475-2571
IDREF: 85228370
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorMAUREL, Delphine B
dc.date.accessioned2025-10-13T08:33:52Z
dc.date.available2025-10-13T08:33:52Z
dc.date.issued2025-08-22
dc.identifier.issn1945-4589en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207796
dc.description.abstractEnWhile blood vessels and osteocytes have been studied independently, their simultaneous changes with age remain undescribed. Our objective was to investigate the age-related evolution of both osteocyte and blood vessel networks in mouse cortical bone, and to assess the associated effects on osteocyte markers and oxygen intracellular levels. We analyzed femurs of male Flk1-GFP mice from growing, mature, middle-aged, and aged groups with techniques such as laser microdissection followed by RT-qPCR, tissue clearing and 3D fluorescence imaging. In the mature animals - when the cortical bone was thicker than in the growing animals - the osteocyte density, the number of dendrites per osteocyte and the blood vessel density were lower. This was associated with a reduced expression of and with a smaller fraction of osteocytes exhibiting low intracellular oxygen. In aged animals - when cortical bone was thinner than in mature animals - the number of dendrites per osteocyte and the blood vessel density were lower. This was associated with a reduced (Cx43) expression. Our results suggest that changes in the osteocyte network during maturation and aging are led by distinct mechanisms, and that the cortical bone blood vessels are not the main source of oxygen for osteocytes.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.titleBlood vessel and osteocyte networks concurrently rearrange during bone maturation and decline during aging in the femur of male mice
dc.title.alternativeAging (Albany NY)en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.18632/aging.206302en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.identifier.pubmed40848274en_US
bordeaux.journalAgingen_US
bordeaux.page2089-2112en_US
bordeaux.volume17en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-05311247
hal.version1
hal.date.transferred2025-10-13T08:33:55Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.title=Blood%20vessel%20and%20osteocyte%20networks%20concurrently%20rearrange%20during%20bone%20maturation%20and%20decline%20during%20aging%20in%20the%20femur%20of%20male%20mice&rft.atitle=Blood%20vessel%20and%20osteocyte%20networks%20concurrently%20rearrange%20during%20bone%20maturation%20and%20decline%20during%20aging%20in%20the%20femur%20of%20male%20mic&rft.jtitle=Aging&rft.date=2025-08-22&rft.volume=17&rft.issue=8&rft.spage=2089-2112&rft.epage=2089-2112&rft.eissn=1945-4589&rft.issn=1945-4589&rft.au=PALMIER,%20Mathilde&MA%C3%8ETRE,%20Marl%C3%A8ne&DOAT,%20H%C3%A9l%C3%A8ne&LEST%C3%89-LASSERRE,%20Thierry&BOIZIAU,%20Claudine&rft.genre=article


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