Anti-adhesion and Anti-inflammatory Potential of the Leaderless Class IIb Bacteriocin Enterocin DD14
| hal.structure.identifier | Biodiversité, Gènes & Communautés [BioGeCo] | |
| dc.contributor.author | TEIAR, Radja | |
| hal.structure.identifier | Biodiversité, Gènes & Communautés [BioGeCo] | |
| dc.contributor.author | PÉREZ-RAMOS, Adrián | |
| hal.structure.identifier | Biodiversité, Gènes & Communautés [BioGeCo] | |
| dc.contributor.author | ZGHEIB, Hassan | |
| hal.structure.identifier | BioEcoAgro - Equipe 7 - Health benefit of protein hydrolysates and agro-food co-products: control of production, characterization and valorisation | |
| dc.contributor.author | CUDENNEC, Benoit | |
| hal.structure.identifier | BioEcoAgro - Equipe 8 - Food and Digestive Microbial Ecosystems: Interactions - Dynamics - Application(s) | |
| dc.contributor.author | BELGUESMIA, Yanath | |
| hal.structure.identifier | BioEcoAgro - Equipe 8 - Food and Digestive Microbial Ecosystems: Interactions - Dynamics - Application(s) | |
| dc.contributor.author | DRIDER, Djamel | |
| dc.date.accessioned | 2025-09-18T02:02:09Z | |
| dc.date.available | 2025-09-18T02:02:09Z | |
| dc.date.issued | 2022-05-23 | |
| dc.identifier.issn | 1867-1306 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/207627 | |
| dc.description.abstractEn | In this study, we investigate the interactions between the leaderless class IIb bacteriocin, enterocin DD14 (EntDD14), or the methicillin or the combination of these antibacterials, and two methicillin-resistant Staphylococcus aureus strains (MRSA-S1 and USA 300) which are respectively a clinical strain and a reference strain. The results obtained showed that EntDD14 alone or in combination with the antibiotic could significantly prevent the adhesion of these pathogenic bacteria to human cells. On the other hand, we investigated the anti-inflammatory effect of EntDD14 on the secretion of pro-inflammatory interleukins, including IL-6 and IL-8. The results show that EntDD14 is able to decrease significantly the secretion of both interleukins on Caco-2 cells following their treatments with lipopolysaccharides. These novel data provide insightful informations to support applications of bacteriocins as therapeutic agents capable as well to defeat pathogenic bacteria and concomitantly limit their inflammatory reactions. | |
| dc.language.iso | en | |
| dc.subject.en | Leaderless class IIb bacteriocin enterocin DD14 | |
| dc.subject.en | Methicillin-resistant Staphylococcus aureus | |
| dc.subject.en | Synergy | |
| dc.subject.en | Human cell line | |
| dc.subject.en | Anti-adhesion | |
| dc.title.en | Anti-adhesion and Anti-inflammatory Potential of the Leaderless Class IIb Bacteriocin Enterocin DD14 | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1007/s12602-022-09954-0 | |
| dc.subject.hal | Informatique [cs]/Biotechnologie | |
| bordeaux.journal | Probiotics and Antimicrobial Proteins | |
| bordeaux.page | 613-619 | |
| bordeaux.volume | 14 | |
| bordeaux.hal.laboratories | BioGeCo (Biodiversité Gènes & Communautés) - UMR 1202 | * |
| bordeaux.issue | 4 | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | INRAE | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-04328322 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-04328322v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Probiotics%20and%20Antimicrobial%20Proteins&rft.date=2022-05-23&rft.volume=14&rft.issue=4&rft.spage=613-619&rft.epage=613-619&rft.eissn=1867-1306&rft.issn=1867-1306&rft.au=TEIAR,%20Radja&P%C3%89REZ-RAMOS,%20Adri%C3%A1n&ZGHEIB,%20Hassan&CUDENNEC,%20Benoit&BELGUESMIA,%20Yanath&rft.genre=article |
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