Phosphorylcholine-based pH-responsive diblock copolymer micelles as drug delivery vehicles: Light scattering, electron microscopy, and fluorescence experiments
| dc.rights.license | open | |
| hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
| dc.contributor.author | GIACOMELLI, Cristiano | |
| hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
| dc.contributor.author | LE MEN, Lucile | |
| hal.structure.identifier | Laboratoire de Chimie des polymères organiques [LCPO] | |
| hal.structure.identifier | Team 1 LCPO : Polymerization Catalyses & Engineering | |
| dc.contributor.author | BORSALI, Redouane | |
| hal.structure.identifier | Imagerie Moléculaire et Nanobiotechnologies - Institut Européen de Chimie et Biologie [IECB] | |
| dc.contributor.author | LAI-KEE-HIM, Josephine | |
| hal.structure.identifier | Imagerie Moléculaire et Nanobiotechnologies - Institut Européen de Chimie et Biologie [IECB] | |
| dc.contributor.author | BRISSON, Alain | |
| hal.structure.identifier | Department of Chemistry [Sheffield] | |
| dc.contributor.author | ARMES, Steven P. | |
| hal.structure.identifier | Biocompatibles UK Ltd | |
| dc.contributor.author | LEWIS, A. L. | |
| dc.date.accessioned | 2020 | |
| dc.date.available | 2020 | |
| dc.date.created | 2006 | |
| dc.date.issued | 2006 | |
| dc.identifier.issn | 1525-7797 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20759 | |
| dc.description.abstractEn | The micellization behavior of a diblock copolymer comprising a highly hydrophilic and biocompatible poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC corona-forming block and a pH-sensitive poly(2-(diisopropylamino)ethyl methacrylate) (PDPA) core-forming block (PMPC-b-PDPA) has been studied by static and dynamic light scattering (SDLS), transmission electron microscopy (TEM), and potentiometry. Self-assembly of PMPC-b-PDPA copolymers with two different DPA volume fractions (Phi DPA) leads to narrowly distributed and structurally distinct spherical micelles, as evidenced by their molecular weight (M-w,M-mic), aggregation number (N,(agg),,), hydrodynamic radius (RH), corona width (M, and core radius (R-c). The excellent potential of these pH-responsive micelles as nanosized drug delivery vehicles was illustrated by the encapsulation of dipyridamole (DIP), a model hydrophobic drug that dissolves in acid solutions and becomes insoluble above pH 5.8, which is comparable to the pK(a),, of the PDPA block. The influence of micelle structure (namely M-w,(mic), N (agg), RH, W, and R,) on drug loading content, drug loading efficiency, partition coefficient, and release kinetics was investigated and confirmed by fluorescence spectroscopy studies. The maximum dipyridamole loadings within PMPC30-b-PDPA(30) (RH = 14.0 nm; W = 4.8 nm; R-c = 9.2 nm) and PMPC30-b-PDPA(60) (RH = 27.1 nm; W = 11.0 nm; R, = 16.1 nm) tr:ticelles were 7 and 12% w/w(p), respectively. This preferential solubilization of DIP into micelles formed by copolymer chains having longer core-forming blocks (i.e., possessing larger core volumes) reflects the larger partition coefficient (K-v) of DIP between the aqueous phase and PMPC(30)b-PDPA(60) inicelles (Kv = 5.7 x 101) compared to PMPC30-b-PDPA(30) micelles (Kv = 1.1 x 10(4)). This enhanced ability Of PMPC30-b-PDPA(60) aggregates to entrap/stabilize small hydrophobic molecules also produces slower release kinetics. Rapid release can be triggered by lowering the pH to induce micellar dissociation. | |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society | |
| dc.subject.en | VESICLES | |
| dc.subject.en | MIXTURES | |
| dc.subject.en | MICELLIZATION | |
| dc.subject.en | POLYMERS | |
| dc.subject.en | POLYELECTROLYTES | |
| dc.subject.en | TRANSFER RADICAL POLYMERIZATION | |
| dc.subject.en | BIOCOMPATIBLE BLOCK-COPOLYMERS | |
| dc.subject.en | SOLUBILIZATION | |
| dc.subject.en | RELEASE | |
| dc.subject.en | PROBES | |
| dc.title.en | Phosphorylcholine-based pH-responsive diblock copolymer micelles as drug delivery vehicles: Light scattering, electron microscopy, and fluorescence experiments | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1021/bm0508921 | |
| dc.subject.hal | Chimie/Polymères | |
| bordeaux.journal | Biomacromolecules | |
| bordeaux.page | 817-828 | |
| bordeaux.volume | 7 | |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
| bordeaux.issue | 3 | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00342105 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00342105v1 | |
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