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Residual sleepiness and impaired alertness in treated obstructive sleep apnoea: role of hypoxic burden and sleep fragmentation

dc.rights.licenseopenen_US
dc.contributor.authorTANKÉRÉ, Pierre
hal.structure.identifierSommeil, Addiction et Neuropsychiatrie [Bordeaux] [SANPSY]
dc.contributor.authorTAILLARD, Jacques
ORCID: 0000-0001-9067-8189
IDREF: 229930786
dc.contributor.authorPETITJEAN, Thierry
dc.contributor.authorLE-CAM, Pierre
dc.contributor.authorRICORDEAU, François
dc.contributor.authorBLANCHARD, Margaux
dc.contributor.authorVANBUIS, Jade
dc.contributor.authorNOFAL, Anice
dc.contributor.authorTAMISIER, Renaud
dc.contributor.authorPETER-DEREX, Laure
dc.contributor.authorSTAUFFER, Emeric
dc.date.accessioned2025-09-01T14:47:13Z
dc.date.available2025-09-01T14:47:13Z
dc.date.issued2025-03
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207551
dc.description.abstractEnThe pathophysiology of residual sleepiness in treated obstructive sleep apnoea (OSA) remains poorly understood. Animal models suggest that it may involve neuronal damage due to intermittent hypoxia and sleep fragmentation. In a cohort of 122 continuous positive airway pressure (CPAP) treated OSA patients referred for maintenance of wakefulness test, we explored the determinants of (objective) alertness and those of (subjective) sleepiness assessed by Epworth Sleepiness Scale.We found that in logistic models, residual hypoxic burden was significatively associated with objective impaired alertness (OR=1.005, 95% CI 1.002 to 1.008), p=0.003), whereas arousal index >25/h was significatively associated with subjective residual sleepiness (OR=1.23, 95% CI 1.05to 1.43, p=0.02). This suggests that hypoxia and sleep fragmentation may be involved in different dimensions of residual hypersomnolence in treated OSA.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enHypoxia
dc.subject.enSleep
dc.subject.enSleep apnoea
dc.title.enResidual sleepiness and impaired alertness in treated obstructive sleep apnoea: role of hypoxic burden and sleep fragmentation
dc.title.alternativeThoraxen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/thorax-2024-222462en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed39832943en_US
bordeaux.journalThoraxen_US
bordeaux.page245-247en_US
bordeaux.volume80en_US
bordeaux.hal.laboratoriesSANPSY (Sommeil, Addiction, Neuropsychiatrie) - UMR 6033en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcecrossref
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcecrossref
dc.rights.ccCC BY-NCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Thorax&rft.date=2025-03&rft.volume=80&rft.issue=4&rft.spage=245-247&rft.epage=245-247&rft.au=TANK%C3%89R%C3%89,%20Pierre&TAILLARD,%20Jacques&PETITJEAN,%20Thierry&LE-CAM,%20Pierre&RICORDEAU,%20Fran%C3%A7ois&rft.genre=article


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