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Effects of the urinary urea excretion index on the decision to wean ICU patients with acute kidney injury from renal replacement therapy: a before-after multicentre study (D-STOP).

dc.rights.licenseopenen_US
dc.contributor.authorBODOT, Simon
dc.contributor.authorGROS, Alexandre
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE GALL, Lisa
IDREF: 222223472
dc.contributor.authorMARTIN, Aurélie
dc.contributor.authorGISBERT-MORA, Chloé
dc.contributor.authorPILLOT, Jerome
dc.contributor.authorRAGOT, Claire
dc.contributor.authorGRAND, Hubert
dc.contributor.authorROMEN, Antoine
dc.contributor.authorMASRI, Alexandre
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorDEWITTE, Antoine
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorGRUSON, Didier
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorPREVEL, Renaud
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorRUBIN, Sebastien
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorORIEUX, Arthur
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorBOYER, Alexandre
dc.date.accessioned2025-09-01T07:49:53Z
dc.date.available2025-09-01T07:49:53Z
dc.date.issued2025-07-01
dc.identifier.issn1466-609Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207539
dc.description.abstractEnThe weaning of critical care patients with acute kidney injury (AKI) from renal replacement therapy (RRT) lacks predictive criteria. The urinary urea excretion index (UUEI) based on the urine urea concentration and diuresis may be a relevant prognostic criterion. The aim of this study was to assess the value of utilising a UUEI-based weaning protocol from a RRT catheter. This was a multicentre before-after study including patients with non-obstructive AKI requiring RRT during their intensive care unit (ICU) stay. A before cohort (2013-2015) was compared to an after cohort (2017-2019) in the interval of which a UUEI-based weaning protocol was implemented. In the after cohort, as soon as the UUEI exceeded 1.35 mmol/kg/24 h, physicians were encouraged to stop RRT and withdraw the catheter, whereas in the before cohort the catheter was withdrawn at the physician's discretion. The primary outcome was the number of RRT catheter-free days on day 28 after initiating RRT. In total, 179 and 130 patients were included in the before and after cohorts, respectively. The median numbers of catheter-free days in the before and after cohorts on day 28 were 13.0 (IQR 0.0-21.0) vs. 16.5 (IQR 4.3-24.0), respectively (p = 0.02). The adjusted rate ratio for the number of catheter-free days over the number of days at risk was 1.11 (95% CI 1.03-1.19; p = 0.006) in favour of the after cohort. Catheters were reinserted to resume RRT in 3 vs. 5 patients in the before  and after cohorts, respectively. These results confirm that a UUEI-based protocol is a safe technique to prompt withdrawal of the RRT catheter in patients with AKI requiring RRT during their ICU stay.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enHumans
dc.subject.enAcute Kidney Injury
dc.subject.enMale
dc.subject.enFemale
dc.subject.enUrea
dc.subject.enRenal Replacement Therapy
dc.subject.enIntensive Care Units
dc.subject.enMiddle Aged
dc.subject.enAged
dc.subject.enCohort Studies
dc.title.enEffects of the urinary urea excretion index on the decision to wean ICU patients with acute kidney injury from renal replacement therapy: a before-after multicentre study (D-STOP).
dc.title.alternativeCrit Careen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s13054-025-05289-8en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed40598590en_US
bordeaux.journalCritical Careen_US
bordeaux.page261en_US
bordeaux.volume29en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-05232431
hal.version1
hal.date.transferred2025-09-01T07:49:57Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Critical%20Care&rft.date=2025-07-01&rft.volume=29&rft.issue=1&rft.spage=261&rft.epage=261&rft.eissn=1466-609X&rft.issn=1466-609X&rft.au=BODOT,%20Simon&GROS,%20Alexandre&LE%20GALL,%20Lisa&MARTIN,%20Aur%C3%A9lie&GISBERT-MORA,%20Chlo%C3%A9&rft.genre=article


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