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How to Manage Venous Thromboembolism Risk during Pregnancy in Patients with Inherited Antithrombin Deficiency?

dc.rights.licenseopenen_US
hal.structure.identifierParis-Centre de Recherche Cardiovasculaire [PARCC (UMR_S 970/ U970)]
dc.contributor.authorMAUGE, Laetitia
dc.contributor.authorMADAR, Hugo
hal.structure.identifierIschémie reperfusion, métabolisme et inflammation stérile en transplantation [U 1313] [IRMETIST [Poitiers]]
dc.contributor.authorCARRÉ, Julie
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorFIORE, Mathieu
hal.structure.identifierF-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] [ Innovte]
hal.structure.identifierHôpital Européen Georges Pompidou [APHP] [HEGP]
hal.structure.identifierParis-Centre de Recherche Cardiovasculaire [PARCC (UMR_S 970/ U970)]
dc.contributor.authorGENDRON, Nicolas
dc.contributor.authorMOUTON, Christine
dc.contributor.authorPROULLE, Valérie
dc.contributor.authorSUCHON, Pierre
hal.structure.identifierCentre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research [C2VN]
dc.contributor.authorTRILLOT, Nathalie
dc.contributor.authorLECHAT, Thomas
dc.contributor.authorSENTILHES, Loïc
hal.structure.identifierIschémie reperfusion, métabolisme et inflammation stérile en transplantation [U 1313] [IRMETIST [Poitiers]]
dc.contributor.authorMACCHI, Laurent
dc.date.accessioned2025-09-01T07:11:46Z
dc.date.available2025-09-01T07:11:46Z
dc.date.issued2025-07-08
dc.identifier.issn0340-6245en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207529
dc.description.abstractEnInherited antithrombin deficiency (ATD) is associated with a high risk of venous thromboembolic complications. Association of ATD with other conditions such as pregnancy obviously increases thromboembolic risk and may require anticoagulant therapy for prevention. Although there are several/heterogenous international guidelines regarding thromboprophylaxis in pregnant patients with ATD, data on anticoagulant prophylaxis in this context are scarce in the literature. Thus, this situation remains a challenge both in the antepartum period and during delivery. Physicians from the French Society of Thrombosis and Haemostasis (SFTH) performed a review of the literature to suggest propositions regarding the management of thrombosis prevention based on anticoagulation and antithrombin substitution in ATD pregnant women. In this review, after reporting the thrombotic risk associated with ATD, the indication of anticoagulant therapy, its dosing regimen and monitoring, and the indication of antithrombin concentrates during pregnancy and the postpartum period are discussed as well as peripartum management. Finally, this work confirms the complex management of thrombotic prevention in pregnant patients with ATD. Indeed, it requires to take into account a multiplicity of features cited in our propositions that will hopefully provide some help in this field. This work also highlights the importance of multidisciplinary discussions for pregnant women with ATD who should be counseled in an expert center including hematologist, obstetrician, and anesthetist to optimize their management.
dc.language.isoENen_US
dc.subject.enPregnancy
dc.subject.enantithrombin deficiency
dc.subject.envenous thrombosis
dc.subject.enThromboprophylaxis
dc.title.enHow to Manage Venous Thromboembolism Risk during Pregnancy in Patients with Inherited Antithrombin Deficiency?
dc.typeArticle de revueen_US
dc.identifier.doi10.1055/a-2650-7959en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed40628415en_US
bordeaux.journalThrombosis and Haemostasisen_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-05216850
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Thrombosis%20and%20Haemostasis&rft.date=2025-07-08&rft.eissn=0340-6245&rft.issn=0340-6245&rft.au=MAUGE,%20Laetitia&MADAR,%20Hugo&CARR%C3%89,%20Julie&FIORE,%20Mathieu&GENDRON,%20Nicolas&rft.genre=article


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