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Risk of cancer in people with HIV experiencing varying degrees of immune recovery with sustained virological suppression on antiretroviral treatment for more than 2 years: an international, multicentre, observational cohort

dc.rights.licenseopenen_US
dc.contributor.authorHAN, Win Min
dc.contributor.authorRYOM, Lene
dc.contributor.authorSABIN, Caroline A
dc.contributor.authorGREENBERG, Lauren
dc.contributor.authorCAVASSINI, Matthias
dc.contributor.authorEGLE, Alexander
dc.contributor.authorDUVIVIER, Claudine
dc.contributor.authorWIT, Ferdinand
dc.contributor.authorMUSSINI, Cristina
dc.contributor.authorD'ARMINIO MONFORTE, Antonella
dc.contributor.authorCASTAGNA, Antonella
dc.contributor.authorMIRO, Jose M
dc.contributor.authorVAN DER VALK, Marc
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorPRADIER, Christian
dc.contributor.authorSKOCIC, Matthias
dc.contributor.authorMATULIONYTE, Raimonda
dc.contributor.authorSTOCKLE, Marcel
dc.contributor.authorJASCHINSKI, Nadine
dc.contributor.authorTIMIRYASOVA, Alisa
dc.contributor.authorTALLADA, Joan
dc.contributor.authorROGATTO, Felipe P
dc.contributor.authorVANNAPPAGARI, Vani
dc.contributor.authorYOUNG, Lital A
dc.contributor.authorLUNDGREN, Jens D
dc.contributor.authorPETOUMENOS, Kathy
dc.contributor.authorHOY, Jennifer F
dc.date.accessioned2025-07-11T08:13:30Z
dc.date.available2025-07-11T08:13:30Z
dc.date.issued2025-05-15
dc.identifier.issn1537-6591en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207311
dc.description.abstractEnBACKGROUND: The impact of long-term virological suppression and CD4 count recovery on non-AIDS defining cancers (NADC) is unclear. We determined whether poor immune recovery was associated with incident cancer risk in people with HIV with virological suppression (VS). METHODS: Participants from the D:A:D and RESPOND collaborations in Europe and Australia who achieved ≥2 years of VS on ART between Dec 1999 and Dec 2022 were included. Follow-up was from baseline (date of VS for two years) until the earliest of a first cancer event, virological failure, final follow-up, or administrative censoring date. Multivariable Poisson regression was used to assess associations between cancer incidence (overall, AIDS-defining cancer (ADC), NADC, infection-related, infection-unrelated) and time-updated CD4 count stratified by pre-ART nadir CD4 counts. RESULTS: Overall, 48,343 people with VS were included (median [IQR] baseline age 43 years [37-50], CD4 count 540 cells/µL [380-730], nadir CD4 count 245 cells/µL [121-394], 74% male). There were 1,933 incident cancers, median 6.2 years [2.9-9.5] (incidence rate (IR): 6.43 [95%CI 6.15-6.73]/1000 person-years). Higher time-updated CD4 count was associated with a reduced risk of overall cancer (adjusted incidence rate ratio [aIRR] for time-updated CD4 350-499: 0.45 [95%CI 0.39-0.51]; 500-749: 0.30 [0.27-0.34], and ≥750: 0.26 [0.23-0.30] vs. <350 cells/µL, p<0.0001). There was a significant reduction in all cancers risk by higher time-updated CD4 count regardless of nadir CD4 count, with higher pre-ART nadir CD4 count exhibiting lower risk. CONCLUSIONS: Despite VS on ART for more than two years, people with poorer immune recovery experience a significantly higher incidence of cancer.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enCancers
dc.subject.enImmune Recovery
dc.subject.enNon-AIDS-Defining Cancers
dc.subject.enPeople With HIV
dc.subject.enVirological Suppression
dc.title.enRisk of cancer in people with HIV experiencing varying degrees of immune recovery with sustained virological suppression on antiretroviral treatment for more than 2 years: an international, multicentre, observational cohort
dc.title.alternativeClin Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cid/ciaf248en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40368374en_US
bordeaux.journalClinical Infectious Diseasesen_US
bordeaux.pageciaf248en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
hal.identifierhal-05157667
hal.version1
hal.date.transferred2025-07-11T08:13:37Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Clinical%20Infectious%20Diseases&amp;rft.date=2025-05-15&amp;rft.spage=ciaf248&amp;rft.epage=ciaf248&amp;rft.eissn=1537-6591&amp;rft.issn=1537-6591&amp;rft.au=HAN,%20Win%20Min&amp;RYOM,%20Lene&amp;SABIN,%20Caroline%20A&amp;GREENBERG,%20Lauren&amp;CAVASSINI,%20Matthias&amp;rft.genre=article


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