A fast protocol for photodynamic therapy in exudative choroidal circumscribed hemangioma: Early laser irradiance after end of verteporfin infusion
| dc.rights.license | open | en_US |
| dc.contributor.author | DUBAR, Paul | |
| dc.contributor.author | MATHIS, Thibaud | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HUCTEAU, Emilie | |
| dc.contributor.author | THARIAT, Juliette | |
| dc.contributor.author | NHARI, Maxime | |
| dc.contributor.author | MASCHI, Celia | |
| dc.contributor.author | FABER, Carsten | |
| dc.contributor.author | KIILGAARD, Jens Folke | |
| dc.contributor.author | MOSCI, Carlo | |
| dc.contributor.author | FAVARD, Catherine | |
| dc.contributor.author | TICK, Sarah | |
| dc.contributor.author | NGUYEN, Anh-Minh | |
| dc.contributor.author | CAUJOLLE, Jean-Pierre | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELYFER, Marie-Noelle | |
| dc.contributor.author | ROSIER, Laurence | |
| dc.date.accessioned | 2025-07-08T11:19:39Z | |
| dc.date.available | 2025-07-08T11:19:39Z | |
| dc.date.issued | 2025-05-05 | |
| dc.identifier.issn | 1755-3768 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/207267 | |
| dc.description.abstractEn | PURPOSE: The aim of the study is to compare the risk of first-line photodynamic therapy (PDT) failure according to the PDT protocol performed in patients with exudative choroidal circumscribed hemangioma (CCH). METHODS: We retrospectively included patients from 11 European centres in France, Italy and Denmark. Two groups were established: patients treated with Standard Protocol PDT (SP-PDT) and patients treated with a 'Fast' Protocol PDT (FP-PDT), characterised by laser irradiation without delay after the end of the verteporfin infusion (8 min after start of infusion). We analysed groups on the risk of exudative CCH recurrence requiring a second line of treatment, defining the first-line PDT failure. RESULTS: A total of 111 patients were included in the study: 76 treated with the SP-PDT and 35 with the FP-PDT. First-line PDT failure was observed for 45 patients (59%) in the SP-PDT group and 9 patients (26%) in the FP-PDT group, with a median follow-up of 3.5 [1.7-6.7] years and 2.3 [0.8-3.9] years, respectively. Final best-corrected visual acuity (BCVA) improvement did not differ between groups (p = 0.49). A multivariate survival analysis including initial CCH thickness and initial BCVA was performed over a two-year follow-up period: FP-PDT as first-line treatment was significantly associated with a lower risk of PDT failure [HR = 0.27, 95%CI (0.11-0.65)]. CONCLUSION: FP-PDT shows encouraging results in the treatment of CCHs, as it is associated with a lower risk of PDT failure. It may therefore represent an interesting avenue for optimised PDT parameters, although these results need to be confirmed by randomised trials. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Choroidal Diseases | |
| dc.subject.en | Choroidal Tumour | |
| dc.subject.en | Circumscribed Choroidal Hemangioma | |
| dc.subject.en | Laser Protocol | |
| dc.subject.en | Onco‐Ophthalmology | |
| dc.subject.en | Photodynamic Therapy | |
| dc.subject.en | Retina | |
| dc.subject.en | Verteporfin | |
| dc.title.en | A fast protocol for photodynamic therapy in exudative choroidal circumscribed hemangioma: Early laser irradiance after end of verteporfin infusion | |
| dc.title.alternative | Acta Ophthalmol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/aos.17513 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 40322789 | en_US |
| bordeaux.journal | Acta Ophthalmologica | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-05150719 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-07-08T11:19:43Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
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