Show simple item record

Tuberculosis disease characteristics associated with mortality, severe morbidity and unsuccessful treatment in people living with HIV treated for tuberculosis - a secondary analysis of the ANRS 12300 Reflate TB2 trial

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorAKPATA, Robert
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorN'TAKPE, Jean-Baptiste
dc.contributor.authorMESSOU, Eugene
dc.contributor.authorDE CASTRO, Nathalie
dc.contributor.authorCHAZALLON, Corine
dc.contributor.authorTIMANA, Isabel
dc.contributor.authorESCADA, Rodrigo
dc.contributor.authorCARDOSO, Sandra Wagner
dc.contributor.authorBHATT, Nilesh
dc.contributor.authorKHOSA, Celso
dc.contributor.authorLAUREILLARD, Didier
dc.contributor.authorDO CHAU, Giang
dc.contributor.authorNOGBOU, Frederic Ello
dc.contributor.authorGLAO, Donald Diomande
dc.contributor.authorVELOSO, Valdilea
dc.contributor.authorMOLINA, Jean-Michel
dc.contributor.authorGRINSZTEJN, Beatriz
dc.contributor.authorZANNOU, Marcel
dc.contributor.authorEHOLIE, Serge
dc.contributor.authorMARCY, Olivier
dc.date.accessioned2025-07-03T14:06:39Z
dc.date.available2025-07-03T14:06:39Z
dc.date.issued2025-05-14
dc.identifier.issn1471-2334en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/207199
dc.description.abstractEnBACKGROUND: Tuberculosis is a severe disease, not only due to its lethality but also to a significant morbidity occurring in people living with HIV (PLWH). If factors associated to mortality, severe morbidity and unsuccessful treatment related to the host are well identified in PLWH, there is scarce knowledge on factors related to the disease itself such as bacillary load, extent of lung involvement and disease dissemination to other organs. We sought to assess whether tuberculosis-related factors were associated with key patient outcomes in PLWH using data from an international clinical trial. METHODS: We conducted a secondary analysis of the ANRS 12300 Reflate TB2, an international phase III open-label randomized trial that assessed different antiretroviral regimens in PLWH treated for tuberculosis. We evaluated whether bacillary load (smear positivity grade), extent of lung involvement (cavitation on chest x-ray) and disease dissemination (urine LAM positivity) were associated with mortality using Cox proportional hazard models, and to severe morbidity and unsuccessful tuberculosis treatment using logistic regressions. RESULTS: Of 457 participants included in this study, 90 (20.4%) had grade 2 + or 3 + smear positivity, 39 (10.8%) had cavitation on chest X-ray, and 147 (32.2%) had a positive urinary LAM. Overall, 19 (4.2%) participants died, 113 (24.7%) presented severe morbidity, and 33 (7.2%) had unsuccessful tuberculosis treatment. Factors that remained independently associated with mortality were cavitation on chest x-ray (aHR = 7.92, 95% CI, 1.74-35.94, p = .0073) and LAM positivity (aHR = 5.53, 95% CI, 1.09-28.06, p = .0389). The only factor that remained significantly associated with severe morbidity was LAM positivity (aOR = 2.04, 95% CI, 1.06-3.92, p = .0323). No factor remained significantly associated with unsuccessful tuberculosis treatment. CONCLUSIONS: In PLWH with tuberculosis enrolled in a trial, tuberculosis disease characteristics related to disease severity were cavitation on chest x-ray and urine LAM positivity. Early identification of these factors could help improve the management of PLWH with tuberculosis and improve their survival.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enBacillary load
dc.subject.enDisease dissemination
dc.subject.enExtent of lung involvement
dc.subject.enHIV
dc.subject.enMortality
dc.subject.enSevere morbidity
dc.subject.enTuberculosis
dc.subject.enUnsuccessful treatment
dc.title.enTuberculosis disease characteristics associated with mortality, severe morbidity and unsuccessful treatment in people living with HIV treated for tuberculosis - a secondary analysis of the ANRS 12300 Reflate TB2 trial
dc.title.alternativeBMC Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s12879-025-10986-4en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed40361016en_US
bordeaux.journalBMC Infectious Diseasesen_US
bordeaux.page695en_US
bordeaux.volume25en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
hal.identifierhal-05142813
hal.version1
hal.date.transferred2025-07-03T14:06:43Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMC%20Infectious%20Diseases&rft.date=2025-05-14&rft.volume=25&rft.issue=1&rft.spage=695&rft.epage=695&rft.eissn=1471-2334&rft.issn=1471-2334&rft.au=AKPATA,%20Robert&N'TAKPE,%20Jean-Baptiste&MESSOU,%20Eugene&DE%20CASTRO,%20Nathalie&CHAZALLON,%20Corine&rft.genre=article


Files in this item

Thumbnail
Name:
BPH_BMCID_2025_Akpata.pdf
Size:
905.5Kb
Format:
PDF
View/Open
Thumbnail
Name:
license_rdf
Size:
811bytes
Format:
application/rdf+xml
View/Open

This item appears in the following Collection(s)

Show simple item record