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Clinical and bronchial parameters associated with the exacerbation frequency of severe preschool wheezers

dc.rights.licenseopenen_US
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorBEAUFILS, Fabien
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorESTEVES, Pauline
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorENAUD, Raphael
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorPREVEL, Renaud
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorHENROT, Pauline
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorCAMPAGNAC, Marilyne
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorMAURAT, Elise
hal.structure.identifierCentre de Physiopathologie Toulouse Purpan [CPTP]
dc.contributor.authorMICHELET, Marine
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorLAVRAND, Frederic
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
dc.contributor.authorBEGUERET, Hugues
dc.contributor.authorTRIAN, Thomas
dc.contributor.authorFAYON, Michael
dc.contributor.authorBERGER, Patrick
dc.contributor.authorSIAO-HIM-FA, Valerie
dc.contributor.authorAURIOL, Françoise
dc.contributor.authorBLANCHON, Sylvain
dc.contributor.authorCARLES, Dominique
dc.contributor.authorBOISSERIE-LACROIX, Vincent
dc.contributor.authorBRÉMONT, François
dc.contributor.authorBUI, Stéphanie
dc.contributor.authorSIMON, Guillaume
dc.contributor.authorCHOUKROUN, Marie-Luce
dc.contributor.authorDEBELLEIX, Stéphane
dc.contributor.authorFEGHALI, Hala
dc.contributor.authorLABOURET, Géraldine
dc.contributor.authorMARTIN BLONDEL, Audrey
dc.contributor.authorMARAIS, Sébastien
dc.contributor.authorMITTAINE, Marie
dc.contributor.authorNACKA, Fabienne
dc.contributor.authorOUSOVA, Olga
dc.contributor.authorROUQUETTE, Isabelle
dc.contributor.authorSEMJEN, François
dc.contributor.authorSGOIFO, Frédérique
dc.date.accessioned2025-06-18T08:46:06Z
dc.date.available2025-06-18T08:46:06Z
dc.date.issued2024-04-01
dc.identifier.issn2213-2198en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206942
dc.description.abstractEnRecurrent preschool wheezers represent approximately 10% of children under 5 years of age. Among them, those who report frequent exacerbations (ie, or more per year), mainly due to viral and/or bacterial infections, have an increased risk of persistent asthma and poor lung function throughout life. The risk of exacerbation has been previously associated with several clinical and/or biological parameters, including those of bronchial remodeling. The latter corresponds to a poorly reversible structural abnormality of the bronchial tissue (ie, altered epithelial integrity, increased mass of mucus gland and/or bronchial smooth muscle [BSM], increased density of blood vessels, and an increased collagen deposition leading to reticular basement membrane [RBM] thickening and increased submucosal fibrosis). However, it remains unclear whether these factors are independently associated with exacerbation frequency (no exacerbation), infrequent (1 or 2) exacerbations, or frequent (≥3) exacerbations. We aimed to identify the parameters independently associated with short-term subsequent exacerbation frequency (ie, within a year) in 80 severe preschool children (1-5 years old). These children have been pooled from 2independent cohorts with the same inclusion criteria (NCT02806466 and NCT04558671), as described previously.3 All children had uncontrolled severe recurrent preschool wheeze despite receiving high doses of inhaled corticosteroids (ICS) and a second controller. Fiberoptic bronchoscopy with bronchial biopsies was performed during the stable period at least weeks after an exacerbation. A detailed description of methods has been previously published elsewhere.
dc.language.isoENen_US
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.meshAsthma / diagnosis
dc.subject.meshAsthma / epidemiology
dc.subject.meshBronchi
dc.subject.meshChild, Preschool
dc.subject.meshEducational Status
dc.subject.meshHumans
dc.subject.meshRespiratory Sounds
dc.title.enClinical and bronchial parameters associated with the exacerbation frequency of severe preschool wheezers
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jaip.2023.12.017en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalJournal of Allergy and Clinical Immunology: In Practiceen_US
bordeaux.page1067-1070en_US
bordeaux.volume12en_US
bordeaux.hal.laboratoriesCentre de Recherche Cardio-Thoracique de Bordeaux (CRCTB) - U1045en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04719634
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Allergy%20and%20Clinical%20Immunology:%20In%20Practice&rft.date=2024-04-01&rft.volume=12&rft.issue=4&rft.spage=1067-1070&rft.epage=1067-1070&rft.eissn=2213-2198&rft.issn=2213-2198&rft.au=BEAUFILS,%20Fabien&ESTEVES,%20Pauline&ENAUD,%20Raphael&PREVEL,%20Renaud&HENROT,%20Pauline&rft.genre=article


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