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Cardiogenic shock and infection: A lethal combination

dc.rights.licenseopenen_US
hal.structure.identifierInstitut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC]
dc.contributor.authorCHERBI, Miloud
hal.structure.identifierCentre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
dc.contributor.authorMERDJI, Hamid
hal.structure.identifierCHU Tenon [AP-HP]
dc.contributor.authorLABBÉ, Vincent
dc.contributor.authorBONNEFOY, Eric
hal.structure.identifierFacteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
dc.contributor.authorLAMBLIN, Nicolas
hal.structure.identifierPhysiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
dc.contributor.authorROUBILLE, François
hal.structure.identifierCentre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
dc.contributor.authorLEVY, Bruno
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorLIM, Pascal
hal.structure.identifierCentre Hospitalier du Pays d'Aix
dc.contributor.authorKHACHAB, Hadi
hal.structure.identifierFacteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
dc.contributor.authorSCHURTZ, Guillaume
hal.structure.identifierHospices Civils de Lyon [HCL]
hal.structure.identifierCentre de Recherche en Acquisition et Traitement de l'Image pour la Santé [CREATIS]
dc.contributor.authorHARBAOUI, Brahim
dc.contributor.authorVANZETTO, Gerald
hal.structure.identifierUniversité Clermont Auvergne [UCA]
dc.contributor.authorCOMBARET, Nicolas
hal.structure.identifierNouvel Hôpital Civil de Strasbourg
dc.contributor.authorMARCHANDOT, Benjamin
hal.structure.identifierCentre Hospitalier Universitaire de Nîmes [CHU Nîmes]
dc.contributor.authorLATTUCA, Benoît
hal.structure.identifierInstitut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC]
dc.contributor.authorBIENDEL-PICQUET, Caroline
hal.structure.identifierCentre Hospitalier Universitaire [Rennes]
hal.structure.identifierLaboratoire Traitement du Signal et de l'Image [LTSI]
dc.contributor.authorLEURENT, Guillaume
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorGERBAUD, Edouard
hal.structure.identifierHôpital Européen Georges Pompidou [APHP] [HEGP]
dc.contributor.authorPUYMIRAT, Etienne
hal.structure.identifierHôpital Nord [CHU - APHM]
dc.contributor.authorBONELLO, Laurent
hal.structure.identifierInstitut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC]
hal.structure.identifierCentre Hospitalier Universitaire de Toulouse [CHU Toulouse]
dc.contributor.authorDELMAS, Clément
dc.date.accessioned2025-06-17T08:37:20Z
dc.date.available2025-06-17T08:37:20Z
dc.date.issued2024
dc.identifier.issn1875-2136en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206932
dc.description.abstractEnBackground: Cardiogenic shock and sepsis are severe haemodynamic states that are frequently present concomitantly, leading to substantial mortality. Despite its frequency and clinical significance, there is a striking lack of literature on the outcomes of combined sepsis and cardiogenic shock.Methods: FRENSHOCK was a prospective registry including 772 patients with cardiogenic shock from 49 centres. The primary endpoint was 1-month all-cause mortality. Secondary endpoints included heart transplantation, ventricular assistance device and all-cause death rate at 1 year.Results: Among the 772 patients with cardiogenic shock included, 92 cases were triggered by sepsis (11.9%), displaying more frequent renal and hepatic acute injuries, with lower mean arterial pressure. Patients in the sepsis group required broader use of dobutamine (90.1% vs 81.2%; P = 0.16), norepinephrine (72.5% vs 50.8%; P < 0.01), renal replacement therapy (29.7% vs 14%; P < 0.01), non-invasive ventilation (36.3% vs 24.4%; P = 0.09) and invasive ventilation (52.7% vs 35.9%; P = 0.02). Sepsis-triggered cardiogenic shock resulted in higher 1-month (41.3% vs 24.0%; adjusted hazard ratio 1.94, 95% confidence interval 1.36–2.76; P < 0.01) and 1-year (62.0% vs 42.9%; adjusted hazard ratio 1.75, 95% confidence interval 1.32–2.33; P < 0.01) all-cause death rates. No significant difference was found at 1 year for heart transplantation or ventricular assistance device (8.7% vs 10.3%; adjusted odds ratio 0.72, 95% confidence interval 0.32–1.64; P = 0.43). In patients with sepsis-triggered cardiogenic shock, neither the presence of a pre-existing cardiomyopathy nor the co-occurrence of other cardiogenic shock triggers had any additional impact on death.Conclusions: The association between sepsis and cardiogenic shock represents a common high-risk scenario, leading to higher short- and long-term death rates, regardless of the association with other cardiogenic shock triggers or the presence of pre-existing cardiomyopathy.
dc.language.isoENen_US
dc.subject.enCardiogenic shock
dc.subject.enSepsis
dc.subject.enEpidemiology
dc.subject.enPrognosis
dc.subject.enMortality
dc.title.enCardiogenic shock and infection: A lethal combination
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.acvd.2024.04.005en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieusesen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaireen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalArchives of cardiovascular diseasesen_US
bordeaux.page470-479en_US
bordeaux.volume117en_US
bordeaux.hal.laboratoriesCentre de Recherche Cardio-Thoracique de Bordeaux (CRCTB) - U1045en_US
bordeaux.issue8-9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04646570
hal.version2
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
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