Parvalbumin interneuron activity in autism underlies susceptibility to PTSD-like memory formation
| dc.rights.license | open | en_US |
| dc.contributor.author | AL ABED, Alice Shaam | |
| dc.contributor.author | ALLEN, Tiarne Vickie | |
| dc.contributor.author | AHMED, Noorya Yasmin | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | SELLAMI, Azza | |
| dc.contributor.author | SONTANI, Yovina | |
| dc.contributor.author | RAWLINSON, Elise Caitlin | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MARIGHETTO, Aline | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | DESMEDT, Aline | |
| dc.contributor.author | DEHORTER, Nathalie | |
| dc.date.accessioned | 2025-06-11T09:28:52Z | |
| dc.date.available | 2025-06-11T09:28:52Z | |
| dc.date.issued | 2024-04-16 | |
| dc.identifier.issn | 2589-0042 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206871 | |
| dc.description.abstractEn | A rising concern in autism spectrum disorder (ASD) is the heightened sensitivity to trauma, the potential consequences of which have been overlooked, particularly upon the severity of the ASD traits. We first demonstrate a reciprocal relationship between ASD and post-traumatic stress disorder (PTSD) and reveal that exposure to a mildly stressful event induces PTSD-like memory in four mouse models of ASD. We also establish an unanticipated consequence of stress, as the formation of PTSD-like memory leads to the aggravation of core autistic traits. Such a susceptibility to developing PTSD-like memory in ASD stems from hyperactivation of the prefrontal cortex and altered fine-tuning of parvalbumin interneuron firing. Traumatic memory can be treated by recontextualization, reducing the deleterious effects on the core symptoms of ASD in the Cntnap2 KO mouse model. This study provides a neurobiological and psychological framework for future examination of the impact of PTSD-like memory in autism. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
| dc.subject.en | Behavioral neuroscience | |
| dc.subject.en | Cellular neuroscience | |
| dc.subject.en | Molecular neuroscience | |
| dc.title.en | Parvalbumin interneuron activity in autism underlies susceptibility to PTSD-like memory formation | |
| dc.title.alternative | iScience | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.isci.2024.109747 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 38741709 | en_US |
| bordeaux.journal | iScience | en_US |
| bordeaux.volume | 27 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Physiopathologie de la mémoire déclarative | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-05107363 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-06-11T09:28:56Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | CC BY-NC | en_US |
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