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Quantitative MRI Biomarkers Measure Changes in Targeted Brain Areas in Patients With Obesity

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBAYNAT, Louise
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorYAMAMOTO, Takayuki
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorTOURDIAS, Thomas
dc.contributor.authorZHANG, Bei
dc.contributor.authorPREVOST, Valentin
dc.contributor.authorINFANTE, Asael
dc.contributor.authorKLEIN, Achille
dc.contributor.authorCAID, Julien
dc.contributor.authorCADART, Olivier
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDOUSSET, Vincent
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCHERIFI, Blandine Gatta
dc.date.accessioned2025-06-10T12:47:00Z
dc.date.available2025-06-10T12:47:00Z
dc.date.issued2024-06-17
dc.identifier.issn0021-972Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206859
dc.description.abstractEnContext: Obesity is accompanied by damages to several tissues, including the brain. Pathological data and animal models have demonstrated an increased inflammatory reaction in hypothalamus and hippocampus. Objective: We tested whether we could observe such pathological modifications in vivo through quantitative magnetic resonance imaging (MRI) metrics. Methods: This prospective study was conducted between May 2019 and November 2022. The study was conducted in the Specialized Center for the Care of Obesity in a French University Hospital. Twenty-seven patients with obesity and 23 age and gender-paired normal-weight controls were prospectively recruited. All participants were examined using brain MRI. Anthropometric and biological data, eating behavior, anxiety, depression, and memory performance were assessed in both groups. The main outcome measure was brain MRI with the following parametric maps: quantitative susceptibility mapping (QSM), mean diffusivity (MD), fractional anisotropy (FA), magnetization transfer ratio map, and T2 relaxivity map. Results: In the hypothalamus, patients with obesity had higher FA and lower QSM than normal-weight controls. In the hippocampus, patients with obesity had higher FA and lower MD. There was no correlation between imaging biomarkers and eating behavior or anxiety. Conclusion: Our findings are consistent with the presence of neuroinflammation in brain regions involved in food intake. In vivo brain biomarkers from quantitative MRI appear to provide an incremental information for the assessment of brain damages in patients with obesity. © The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved.
dc.description.sponsorshipFrance Life Imaging - ANR-11-INBS-0006en_US
dc.language.isoENen_US
dc.subject.enObesity
dc.subject.enHypothalamus
dc.subject.enHippocampus
dc.subject.enNeuroinflammation
dc.title.enQuantitative MRI Biomarkers Measure Changes in Targeted Brain Areas in Patients With Obesity
dc.title.alternativeJ Clin Endocrinol Metaben_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1210/clinem/dgae014en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed38195765en_US
bordeaux.journalJournal of Clinical Endocrinology and Metabolismen_US
bordeaux.page1850 – 1857en_US
bordeaux.volume109en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.teamPhysiopathologie de l'équilibre énergétique et obésitéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05105580
hal.version1
hal.date.transferred2025-06-10T12:47:03Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Clinical%20Endocrinology%20and%20Metabolism&rft.date=2024-06-17&rft.volume=109&rft.issue=7&rft.spage=1850%20%E2%80%93%201857&rft.epage=1850%20%E2%80%93%201857&rft.eissn=0021-972X&rft.issn=0021-972X&rft.au=BAYNAT,%20Louise&YAMAMOTO,%20Takayuki&TOURDIAS,%20Thomas&ZHANG,%20Bei&PREVOST,%20Valentin&rft.genre=article


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